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- Title
Proliferation and osteogenic differentiation of human mesenchymal stem cells on zirconia and titanium with different surface topography.
- Authors
Tomoki HIRANO; Hodaka SASAKI; Shinya HONMA; Yoshitaka FURUYA; Tadashi MIURA; Yasutomo YAJIMA; Masao YOSHINARI
- Abstract
The purpose of this study was to elucidate behavior of human mesenchymal stem cells (hMSCs) on yttria stabilized tetragonal zirconia polycrystals (TZP) and commercial pure titanium (CpTi) with different surface topography. Mirror-polished (MS), sandblasted with 150-μm alumina (SB150) and SB150 acid-etched (SB150E) were prepared on TZP and CpTi. Proliferation, osteogenic differentiation of hMSCs was evaluated. The scanning electron microscopy showed that micro- and nano-topographies were created on both TZP and CpTi SB150E surfaces. The proliferation ability, ALP activity, expression of Runx2 on the both SB150E specimens was significantly higher than those on the other specimens. These results suggested that creation of micro- and nano-topographies on TZP and CpTi by blast and acid-etching may offer a promising method for enhancing the proliferation and differentiation of hMSCs in clinical application.
- Subjects
MESENCHYMAL stem cell differentiation; CELL proliferation; BONE growth; SURFACE topography; ZIRCONIUM oxide; TITANIUM
- Publication
Dental Materials Journal, 2015, Vol 34, Issue 6, p872
- ISSN
0287-4547
- Publication type
Article
- DOI
10.4012/dmj.2015-129