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- Title
Angiogenesis and Inflammatory Bowel Disease.
- Authors
Azzam, Nahla
- Abstract
Inflammatory bowel disease (IBD) has gained immense attention recently due primarily to increasing prevalence. The exact disease mechanism is still unknown. There is considerable evidence of interrelation between the mechanisms of angiogenesis and the chronic inflammation of IBD. This evidence was obtained from animal models of colitis and confirmed in human studies. Serum levels of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (b-FGF) have been found to be significantly higher in patients with IBD than in controls. In addition, it was found that these factors correlate well with disease activity and decrease with the use of steroids. Therefore pharmacological inhibition of angiogenesis has the potential to be a therapeutic strategy in IBD.
- Subjects
NEOVASCULARIZATION; INFLAMMATORY bowel diseases; SERUM; VASCULAR endothelial growth factors; FIBROBLAST growth factors; STEROIDS
- Publication
Saudi Journal of Gastroenterology, 2007, Vol 13, Issue 1, p37
- ISSN
1319-3767
- Publication type
Article
- DOI
10.4103/1319-3767.30464