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- Title
Transmission disequilibrium analysis of the functional 5-HT <sub>3A</sub> receptor variant C178T in early-onset obsessive-compulsive disorder.
- Authors
Mössner, Rainald; Döring, Nicole; Scherag, André; Schäfer, Helmut; Herpertz-Dahlmann, Beate; Remschmidt, Helmut; Schulz, Eberhard; Renner, Tobias; Wewetzer, Christoph; Warnke, Andreas; Lesch, Klaus-Peter; Walitza, Susanne
- Abstract
The 5-HT3 receptor is unique among the serotonin receptors in that it is a ligand-gated ion channel. Dysfunction of the serotonin system is thought to contribute to the pathogenesis of obsessive-compulsive disorder (OCD). Apart from the standard treatment with serotonin reuptake inhibitors and behavioural therapy, a 5-HT3 receptor antagonist has recently been shown to benefit some OCD patients, suggesting the 5-HT3 receptor as a serotonergic candidate gene in the polygenic aetiology of OCD. A functional regulatory variant of the 5-HT3A receptor influences 5-HT3 receptor expression, serotonin metabolites in cerebrospinal fluid, and amygdala reactivity. We therefore assessed whether this C178T variant influences the risk of developing OCD. In a family-based approach employing the transmission disequilibrium test, we analysed a unique sample of 75 children and adolescents with OCD, as well as their biological parents. We found no evidence for a preferential transmission of either allele to the patients - the estimated transmission rate for the C allele was 0.51 (95% CI 0.36-0.65). This argues against an involvement of the 5-HT3A receptor in the polygenic aetiology of early-onset OCD.
- Subjects
SEROTONIN uptake inhibitors; OBSESSIVE-compulsive disorder; ION channels; METABOLITES; CEREBROSPINAL fluid
- Publication
Journal of Psychopharmacology, 2007, Vol 21, Issue 8, p833
- ISSN
0269-8811
- Publication type
Article
- DOI
10.1177/0269881106073560