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- Title
EFFECTS OF DIETARY ROYAL JELLY ON EPIDERMAL GENERATION OF CERAMIDES FROM ACIDIC SPHINGOMYELIN AND GLUCOSYLCERAMIDES IN UV-IRRADIATED HAIRLESS MICE.
- Authors
Juyoung Kim; Yunju Lee; Yunhi Cho
- Abstract
Ultraviolet (UV) irradiation induces skin dryness, mainly via disruption of the epidermal barrier. In an effort to identify dietary agents capable of preventing skin dryness, we investigated the effects of royal jelly on epidermal levels of ceramides (Cer), the major lipid responsible for maintaining the epidermal barrier. Albino hairless mice were fed either a control diet (UV groups) or diets containing 1% royal jelly (RJ) harvested from Cheolwon (group RJ1) or Pocheon (group RJ2) in Korea or imported from China (group RJ3) for 6 wks in parallel with UV irradiation. In groups RJ1 and RJ2, the levels of epidermal Cers 1, 2, 5 and 7 as well as glucosylceramide (GlcCer) 2 were higher than those in the UV- and UV+ groups. Furthermore, protein abundance of acidic sphingomyelinase (A-SMase) and b-glucocerebrosidase (GlcCerase), which are enzymes responsible for generating ceramides, were higher in the RJ1 group than in the UV+ group. Our results demonstrate that the RJ used for the RJ1 group may beneficially alter factors influencing skin dryness, including natural moisturizing factors.
- Subjects
ROYAL jelly; ULTRAVIOLET radiation; SKIN discoloration; CERAMIDES; EPIDERMAL diseases
- Publication
Current Topics in Nutraceutical Research, 2012, Vol 10, Issue 3/4, p151
- ISSN
1540-7535
- Publication type
Article