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- Title
B7-H3 expression is associated with high PD-L1 expression in clear cell renal cell carcinoma and predicts poor prognosis.
- Authors
Lee, Jung Hee; Kim, Yong Jun; Ryu, Hyun Woo; Shin, Seung Won; Kim, Eun Ji; Shin, So Hyun; Park, Joon Young; Kim, So Young; Hwang, Chung Su; Na, Joo-Young; Shin, Dong Hoon; Kim, Jee Yeon; Lee, Hyun Jung
- Abstract
Background: Clear cell Renal cell carcinoma (ccRCC) is an immunogenic tumor. B7 family members, such as CTLA-4, PD-1, and PD-L1, are the main components of immune checkpoints that regulate various immune responses. Specifically, B7-H3 regulates T cell-mediated immune responses against cancer. This study aimed to analyze the association between B7-H3 and CTLA-4 expression and the prognostic factors of ccRCC to provide a basis for their potential use as predictive factors and in immunotherapy. Methods: Formalin-fixed paraffin-embedded specimens were obtained from 244 ccRCC patients, and B7-H3, CTLA-4, and PD-L1 expressions were evaluated using immunohistochemical staining. Results: B7-H3 and CTLA-4 were positive in 73 (29.9%) and 57 (23.4%) of the 244 patients, respectively. B7-H3 expression was significantly associated with PD-L1 expression (P < 0.0001); however, CTLA-4 expression was not (P = 0.842). Kaplan–Meier analysis showed that positive B7-H3 expression was associated with poor progression-free survival (PFS) (P < 0.0001), whereas CTLA-4 expression was not (P = 0.457). Multivariate analysis revealed that B7-H3 was correlated with poor PFS (P = 0.031), whereas CTLA-4 was not (P = 0.173). Conclusions: To the best of our knowledge, this study is the first to investigate B7-H3 and PD-L1 expression and survival in ccRCC. B7-H3 expression is an independent prognostic factor for ccRCC. Furthermore, multiple immune cell inhibitory targets, such as B7-H3 and PD-L1, can be used for therapeutic tumor regression in a clinical setting.
- Subjects
PROGRAMMED cell death 1 receptors; RENAL cell carcinoma; PROGRAMMED death-ligand 1; IMMUNE checkpoint proteins; IMMUNOSTAINING; CYTOTOXIC T lymphocyte-associated molecule-4
- Publication
Diagnostic Pathology, 2023, Vol 18, Issue 1, p1
- ISSN
1746-1596
- Publication type
Article
- DOI
10.1186/s13000-023-01320-0