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- Title
Non-coding RNAs in chromatin folding and nuclear organization.
- Authors
Razin, Sergey V.; Gavrilov, Alexey A.
- Abstract
One of the most intriguing questions facing modern biology concerns how the genome directs the construction of cells, tissues, and whole organisms. It is tempting to suggest that the part of the genome that does not encode proteins contains architectural plans. We are still far from understanding how these plans work at the level of building tissues and the body as a whole. However, the results of recent studies demonstrate that at the cellular level, special non-coding RNAs serve as scaffolds for the construction of various intracellular structures. The term "architectural RNAs" was proposed to designate this subset of non-coding RNAs. In this review, we discuss the role of architectural RNAs in the construction of the cell nucleus and maintenance of the three-dimensional organization of the genome.
- Subjects
NON-coding RNA; CELL nuclei; CHROMATIN; ARCHITECTURAL designs; RNA
- Publication
Cellular & Molecular Life Sciences, 2021, Vol 78, Issue 14, p5489
- ISSN
1420-682X
- Publication type
Article
- DOI
10.1007/s00018-021-03876-w