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- Title
The emerging roles of ribosomal histidyl hydroxylases in cell biology, physiology and disease.
- Authors
Bundred, James R.; Hendrix, Eline; Coleman, Mathew L.
- Abstract
Hydroxylation is a novel protein modification catalyzed by a family of oxygenases that depend on fundamental nutrients and metabolites for activity. Protein hydroxylases have been implicated in a variety of key cellular processes that play important roles in both normal homeostasis and pathogenesis. Here, in this review, we summarize the current literature on a highly conserved sub-family of oxygenases that catalyze protein histidyl hydroxylation. We discuss the evidence supporting the biochemical assignment of these emerging enzymes as ribosomal protein hydroxylases, and provide an overview of their role in immunology, bone development, and cancer.
- Subjects
HYDROXYLASES; CYTOLOGY; RIBOSOMES; POST-translational modification; CONSERVED sequences (Genetics); CANCER immunology; PHYSIOLOGY
- Publication
Cellular & Molecular Life Sciences, 2018, Vol 75, Issue 22, p4093
- ISSN
1420-682X
- Publication type
Article
- DOI
10.1007/s00018-018-2903-z