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- Title
'Mendelian randomization' equals instrumental variable analysis with genetic instruments.
- Authors
Wehby, George L.; Ohsfeldt, Robert L.; Murray, Jeffrey C.
- Abstract
Interest in instrumental variable (IV) analyses using genetic instruments has been growing over the past 4 years. The background, strength and weaknesses of this approach, which in the epidemiology literature has been referred to as 'Mendelian randomization', has been recently reviewed by Lawlor et al. ( Statist. Med. 2007. DOI: ). We suggest a change in the nomenclature of 'Mendelian randomization' and discuss issues relevant to IV analysis including instrument validation, motivation of IV analysis and interpretation of IV estimates in order to motivate a more consistent and standard use of IV analysis across applications using genetic instruments. Copyright © 2008 John Wiley & Sons, Ltd.
- Publication
Statistics in Medicine, 2008, Vol 27, Issue 15, p2745
- ISSN
0277-6715
- Publication type
Article
- DOI
10.1002/sim.3255