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- Title
How does allergen immunotherapy‐induced tolerance improve the airway epithelial barrier function: A mechanistical‐driven hypothesis.
- Authors
Pfaar, Oliver; Fritzsching, Benedikt; Wolf, Hendrik; Woehlk, Christian; Wüstenberg, Eike
- Abstract
How does allergen immunotherapy-induced tolerance improve the airway epithelial barrier function: A mechanistical-driven hypothesis Abbreviations AA allergic asthma AIT allergen immunotherapy AR allergic rhinitis DBPC double-blind, placebo-controlled HDM house dust mite ICS inhaled corticosteroids IFN interferon INS intranasal corticosteroids LABA long-acting beta-agonists NNT number needed to treat PAR protease-activated-receptor SABA short-acting beta-agonists TLR toll-like receptor In recent years, there has been a growing emphasis on understanding the critical importance of the epithelial barrier and exploring various mechanisms that contribute to the onset and progression of allergic, autoimmune, and neurodegenerative disorders. In the GRAZAX® asthma prevention (GAP) trial, children treated with the SQ grass SLIT tablet had a significantly reduced risk of developing asthma symptoms and to use asthma medication.[5] This was, surprisingly, not only observed in summer during grass pollen exposure but also during winter without grass pollen exposure.
- Subjects
ALLERGENS; IMMUNOGLOBULIN E; METHACHOLINE chloride; PULMONARY alveolar proteinosis; AIRWAY (Anatomy); MACROPHAGE colony-stimulating factor; CORPORATE directors; THYMIC stromal lymphopoietin; ATOPY
- Publication
Allergy, 2023, Vol 78, Issue 10, p2577
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.15835