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- Title
Primary Sclerosing Cholangitis: Gender Effects in Valencia's Low-Prevalence Region.
- Authors
Mínguez, Alejandro; Conde, Isabel; Montón, Cristina; Gonzalez, Lara; Pascual, Sonia; Antón, María Dolores; Palau, Antonio; Forés, Ana; Gisbert, Concha; Ojeda, Asunción; Girona, Eva; Di Maira, Tommaso; Berenguer, Marina
- Abstract
Background and Aims: Recent studies point out to epidemiological changes in primary sclerosing cholangitis (PSC). Our aims were to determine in PSC patients followed in several centers in a Mediterranean geographic area: (i) changes in baseline features and (ii) effect of gender on clinical course. Methods: Retrospective multicenter study of PSC patients treated in 8 hospitals in a Mediterranean area between 2000 and 2021. Charts were reviewed compiling demographic, clinical, radiological, and histological variables. Results: Cohort of 112 PSC patients included, 42% women, 70% diagnosed after 2010. Women were increasingly diagnosed in recent cohorts. The median time from diagnosis to the combined endpoint liver transplantation (Lt) and/or death was 6.9 years. Asthenia at diagnosis (p = 0.009) was associated with lower transplant-free survival, while diagnosis before 2005 was associated with greater LT-free survival (p < 0.001). By Cox regression, LT-free survival was not influenced by age, sex, or cirrhosis at the time of diagnosis. Women were found to have less jaundice at diagnosis (2 vs 14%; p = 0.013), higher prevalence of ANA antibodies (43.9 vs 15.7%; p = 0.003), and lower GGT levels at diagnosis (GGT 123 vs 209U/L; p = 0.014) than men. Conclusion: In an area traditionally considered to have low prevalence, the prevalence of affected women surpasses expectations based on existing literature. There appear to be gender-related variations in the presentation of the condition, highlighting the need for confirmation through larger-scale studies.
- Subjects
VALENCIA (Spain); CHOLANGITIS; LIVER transplantation; GENDER; INFLAMMATORY bowel diseases
- Publication
Digestive Diseases & Sciences, 2024, Vol 69, Issue 5, p1863
- ISSN
0163-2116
- Publication type
Article
- DOI
10.1007/s10620-024-08368-y