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- Title
Quantitative and predictive model of transcriptional control of the Drosophila melanogaster even skipped gene.
- Authors
Janssens, Hilde; Hou, Shuling; Jaeger, Johannes; Kim, Ah-Ram; Myasnikova, Ekaterina; Sharp, David; Reinitz, John
- Abstract
Here we present a quantitative and predictive model of the transcriptional readout of the proximal 1.7 kb of the control region of the Drosophila melanogaster gene even skipped (eve). The model is based on the positions and sequence of individual binding sites on the DNA and quantitative, time-resolved expression data at cellular resolution. These data demonstrated new expression features, first reported here. The model correctly predicts the expression patterns of mutations in trans, as well as point mutations, insertions and deletions in cis. It also shows that the nonclassical expression of stripe 7 driven by this fragment is activated by the protein Caudal (Cad), and repressed by the proteins Tailless (Tll) and Giant (Gt).
- Subjects
CYTOGENETICS; GENE expression; CELLULAR control mechanisms; GENETIC regulation; PREDICTION models; DROSOPHILA melanogaster genetics
- Publication
Nature Genetics, 2006, Vol 38, Issue 10, p1159
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng1886