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- Title
A comparative study of apparent diffusion coefficient and intravoxel incoherent motion-derived parameters for the characterization of common solid hepatic tumors.
- Authors
Zhu, Liuhong; Cheng, Qihua; Luo, Wenbin; Bao, Lijun; Guo, Gang
- Abstract
<bold>Background: </bold>The performance of diffusion-weighted imaging parameters for characterizing hepatic tumors is controversial.<bold>Purpose: </bold>To compare the performances of apparent diffusion coefficient (ADC) and intravoxel incoherent motion (IVIM)-derived parameters, including the pure diffusion coefficient (D), perfusion coefficient (D*), and perfusion fraction (f), in the characterization of common solid hepatic tumors.<bold>Material and Methods: </bold>Twelve healthy volunteers and 43 patients underwent free-breath diffusion-weighted magnetic resonance imaging (DW-MRI) of the liver using eight b values (10-800 s/mm(2)). Twelve regions of interest (ROIs) of normal liver tissue in healthy volunteers and 49 hepatic lesions (23 hepatocellular carcinomas [HCCs], 16 hemangiomas, and 10 metastases) were measured. Conventional ADC(0,500) and ADCtotal obtained by the mono-exponential model, as well as D, D*, and f were calculated. Student t-tests and receiver operating characteristic (ROC) analysis were also performed.<bold>Results: </bold>ADC(0,500), ADCtotal, and D were significantly lower in the malignant group ([1.48 ± 0.35] × 10(-3) mm(2)/s; [1.35 ± 0.30] × 10(-3) mm(2)/s; [1.18 ± 0.33] × 10(-3) mm(2)/s) compared to the hemangioma group ([2.74 ± 1.03] × 10(-3) mm(2)/s; [2.61 ± 0.81] × 10(-3) mm(2)/s; [1.97 ± 0.79] × 10(-3) mm(2)/s]. D* did not differ among multiple comparisons. For the area under the ROC curve (AUC-ROC), the maximum value was attained with ADCtotal (0.983) and was closely followed by ADC(0,500) (0.967), with lower values obtained for D (0.837), f (0.649), and D* (0.599). Statistically significant differences were found between the AUC-ROC of both ADCs (ADCtotal and ADC(0,500)) and D. There was no statistically significant difference between the AUC-ROC of ADCtotal and ADC(0,500).<bold>Conclusion: </bold>ADCs showed superior diagnostic performance compared to IVIM-derived parameters in detecting differences between the malignant group and hemangioma group.
- Subjects
COMPARATIVE studies; DIGITAL image processing; LIVER; LIVER tumors; MAGNETIC resonance imaging; RESEARCH methodology; MEDICAL cooperation; MOTION; RESEARCH; RESEARCH evaluation; EVALUATION research; RECEIVER operating characteristic curves
- Publication
Acta Radiologica, 2015, Vol 56, Issue 12, p1411
- ISSN
0284-1851
- Publication type
journal article
- DOI
10.1177/0284185114559426