We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Predicting cardiotoxicity propensity of the novel iodinated contrast medium GE-145: Ventricular fibrillation during left coronary arteriography in pigs.
- Authors
Chai CM; Rasmussen H; Eriksen M; Hvoslef AM; Evans P; Newton BB; Videm S; Chai, Chun-Ming; Rasmussen, Henrik; Eriksen, Morten; Hvoslef, Anne-Marie; Evans, Paul; Newton, Ben B; Videm, Signe
- Abstract
<bold>Background: </bold>Severe side effects caused by iodinated radiographic contrast media (CM) are rare, but can occur in high risk patients and during percutaneous coronary intervention. To minimize this risk a new nonionic CM with low inherent osmolality has been designed, giving room for a relatively high concentration of favorable electrolytes in the isotonic formulation.<bold>Purpose: </bold>To test a new radiographic CM (GE-145) in a pig model of cardiotoxicity by comparing its ventricular fibrillation (VF) propensity and hemodynamic effects to that of iodixanol.<bold>Material and Methods: </bold>Test agents were injected into the left anterior descending coronary artery (LAD) of pigs through an inflated balloon catheter (injection volume 25 ml, injection rate 0.4 ml/s, maximum injection time 62.5 s). Series 1: GE-145 (338 mg I/ml) + 45 mM NaCl and iodixanol (321 mg I/ml) + 19 mM NaCl were injected in five pigs. Series 2: GE-145 (320 mg I/ml) + 45 mM NaCl + 0.1, 0.3, or 0.7 mM CaCl₂ and iodixanol (320 mg I/ml) + 19 mM NaCl + 0.3 mM CaC₂ (Visipaque) were injected in six pigs.<bold>Results: </bold>Iodixanol + NaCl caused VF in 6 of 13 injections (46%) after 60.3±7.5 s (mean ± SD). GE-145 + NaCl did not cause any VF in 13 injections (0%) (P<0.05). Iodixanol + 19 mM NaCl + 0.3 mM CaCl₂ caused VF in 9 of 9 injections (100%) after 61±4 s. GE-145 + 45 mM NaCl + 0.1, 0.3, or 0.7 mM CaCl₂ did not cause any VF during or after 9 injections of each agent (0%) (P<0.05). The least hemodynamic effects were seen with GE-145 + 45 mM NaCl + 0.7 mM CaCl₂.<bold>Conclusion: </bold>In this model of direct administration of CM into the LAD of anesthetized pigs, the tested GE-145 formulations had a significantly lower propensity to induce VF than iodixanol with electrolytes. Favorable hemodynamic properties of GE-145 can be achieved by optimizing concentrations of sodium and calcium.
- Subjects
VENTRICULAR fibrillation; CONTRAST media; NONIONIC contrast media; HEART anatomy; ARTERIES; HEMODYNAMICS; LABORATORY swine
- Publication
Acta Radiologica, 2010, Vol 51, Issue 9, p1007
- ISSN
0284-1851
- Publication type
journal article
- DOI
10.3109/02841851.2010.504743