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- Title
Effects of testosterone and progressive resistance exercise in healthy, highly functioning older men with low-normal testosterone levels.
- Authors
Hildreth, Kerry L; Barry, Daniel W; Moreau, Kerrie L; Vande Griend, Joseph; Meacham, Randall B; Nakamura, Tammie; Wolfe, Pamela; Kohrt, Wendy M; Ruscin, J Mark; Kittelson, John; Cress, M Elaine; Ballard, Robert; Schwartz, Robert S
- Abstract
<bold>Context: </bold>Aging in men is associated with reduced testosterone (T) levels and physiological changes leading to frailty, but the benefits of T supplementation are inconclusive.<bold>Objective: </bold>We studied the effects of T supplementation with and without progressive resistance training (PRT) on functional performance, strength, and body composition.<bold>Design, Setting, and Participants: </bold>We recruited 167 generally healthy community-dwelling older men (66 ± 5 years) with low-normal baseline total T levels (200-350 ng/dL).<bold>Intervention: </bold>Subjects were randomized to placebo or transdermal T gel [2 doses targeting either a lower (400-550 ng/dL) or higher (600-1000 ng/dL) T range] and to either PRT or no exercise for 12 months.<bold>Main Outcome Measure: </bold>The primary outcome was functional performance, whereas secondary outcomes were strength and body composition.<bold>Results: </bold>A total of 143 men completed the study. At 12 months, total T was 528 ± 287 ng/dL in subjects receiving any T and 287 ± 65 ng/dL in the placebo group. In the PRT group, function and strength were not different between T- and placebo-treated subjects, despite greater improvements in fat mass (P = .04) and fat-free mass (P = .01) with T. In the non-PRT group, T did not improve function but improved fat mass (P = .005), fat-free mass (P = .03), and upper body strength (P = .03) compared with placebo. There were fewer cardiovascular events in the T-treated groups compared with placebo.<bold>Conclusions: </bold>T supplementation was well tolerated and improved body composition but had no effect on functional performance. T supplementation improved upper body strength only in nonexercisers compared with placebo.
- Publication
Journal of Clinical Endocrinology & Metabolism, 2013, Vol 98, Issue 5, p1891
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/jc.2012-3695