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- Title
Synthesis, Characterization and Cytotoxicity Evaluation of New Biimidazole Palladium(II) Complexes with Thioureas.
- Authors
Spinardi Franchi, Silmar José; de Souza, Rodrigo Alves; Eduardo Mauro, Antonio; Zeppone Carlos, Iracilda; de Abreu Ribeiro, Livia Carolina; Vieira Rocha, Fillipe; de Godoy-Netto, Adelino Viera
- Abstract
The reactions between [PdCl2(tmbiimH2)]•H2O (1) {tmbiimH2 = 2,2'-bis(4,5-dimethylimidazole)} and thiourea (tu), N-methylthiourea (mtu), N-phenylthiourea (ptu), N,N'-dimethylthiourea (dmtu) or N,N'-diphenylthiourea (dptu) in the 1:2 molar ratio resulted in the compounds [PdL2(tmbiimH2)]Cl2•nH2O {L = tu (2), mtu (3), ptu (4), dmtu (5) and dptu (6)}, which were characterized by elemental analyses, infrared (IR), and 1H NMR spectroscopies and conductivity measurements. The IR spectra of 1-6 were consistent with the presence of chelating tmbimH2 ligand. All compounds and cisplatin were tested in vitro by MTT assay for their cytotoxicity against three murine cancer cell lines: mammary adenocarcinoma (LM3), lung adenocarcinoma (LP07) and mouse fibroblast (L929) cells. Relating the series of compounds to their biological activities we found compound 6 as the most promising of them.
- Subjects
PALLADIUM compounds; THIOUREA; NUCLEAR magnetic resonance spectroscopy; CISPLATIN; LUNG cancer; CANCER cells
- Publication
Acta Chimica Slovenica, 2018, Vol 65, Issue 3, p547
- ISSN
1318-0207
- Publication type
Article
- DOI
10.17344/acsi.2017.4112