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- Title
Influence of nonylphenol and octylphenol exposure on 5-HT, 5-HT transporter, and 5-HT receptor.
- Authors
Liu, Chunhong; Lai, Yuting; Ouyang, Junyan; Yang, Tongwang; Guo, Youting; Yang, Jie; Huang, Shaowen
- Abstract
Nonylphenol (NP) and octylphenol (OP) are priority environmental contaminants that have a potential role as endocrine disruptors. They can be biomagnified in the food chain and pose an estrogenic health risk to human health. A 28-day oral toxicity study was performed to observe the impact of single and combined exposure to NP and OP on 5-HT transporter (SERT) as well as 5-HT receptor. Results showed that the 5-HT levels in rat plasma increased with exposure to middle-dose and high-dose NP, to high-dose OP, and to low, middle, and high doses of combined NP and OP ( P < 0.05), while the 5-HT levels in rat platelets increased when exposed to NP/OP or combined NP and OP of middle or high dose ( P < 0.05). The expression levels of SERT in rat platelets decreased when exposed to high-dose NP/OP or high dose of combined NP and OP ( P < 0.05). Meanwhile, the expression levels of 5-HT in rat platelets decreased when exposed to high-dose NP/OP as well as combined NP and OP ( P < 0.05). These findings suggested that exposure to NP and OP could influence the metabolic network of 5-hydroxytryptamine via transportation and receptor binding pathways.
- Subjects
NONYLPHENOL &; the environment; SEROTONIN receptors; ENDOCRINE disruptors; POLLUTANTS; FOOD chains
- Publication
Environmental Science & Pollution Research, 2017, Vol 24, Issue 9, p8279
- ISSN
0944-1344
- Publication type
Article
- DOI
10.1007/s11356-017-8487-6