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- Title
Radiobiology of Proton Therapy in Human Papillomavirus-Negative and Human Papillomavirus-Positive Head and Neck Cancer Cells.
- Authors
Dok, Rüveyda; Vanderwaeren, Laura; Verstrepen, Kevin J.; Nuyts, Sandra
- Abstract
Simple Summary: Our understanding of the underlying biology of proton therapy in head and neck cancers is limited. Here, we assessed the proton therapy-related radiobiological processes in head and neck cancer cells. We showed that proton therapy resulted in biological effects similar to those of classical photon-based radiotherapy. Photon-based radiotherapy (XRT) is one of the most frequently used treatment modalities for HPV-negative and HPV-positive locally advanced head and neck squamous cell carcinoma (HNSCC). However, locoregional recurrences and normal RT-associated toxicity remain major problems for these patients. Proton therapy (PT), with its dosimetric advantages, can present a solution to the normal toxicity problem. However, issues concerning physical delivery and the lack of insights into the underlying biology of PT hamper the full exploitation of PT. Here, we assessed the radiobiological processes involved in PT in HPV-negative and HPV-positive HNSCC cells. We show that PT and XRT activate the DNA damage-repair and stress response in both HPV-negative and HPV-positive cells to a similar extent. The activation of these major radiobiological mechanisms resulted in equal levels of clonogenic survival and mitotic cell death. Altogether, PT resulted in similar biological effectiveness when compared to XRT. These results emphasize the importance of dosimetric parameters when exploiting the potential of increased clinical effectiveness and reduced normal tissue toxicity in PT treatment.
- Subjects
PROTON therapy; SQUAMOUS cell carcinoma; CANCER relapse; RESEARCH funding; HEAD &; neck cancer; PAPILLOMAVIRUSES; RADIATION dosimetry; RADIOBIOLOGY; CELL lines; DNA damage; CELL death
- Publication
Cancers, 2024, Vol 16, Issue 11, p1959
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers16111959