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- Title
Apolipoprotein E gene polymorphism and the risk of intracerebral hemorrhage: a meta-analysis of epidemiologic studies.
- Authors
Rongjun Zhang; Xiaofeng Wang; Zongchun Tang; Jianxin Liu; Shuzhen Yang; Youbing Zhang; Yijun Wei; Wenyin Luo; Jun Wang; Jialong Li; Bobo Chen; Kunhu Zhang
- Abstract
Background: Studies investigating the association between the apolipoprotein E (APOE) gene polymorphism and the risk of intracerebral hemorrhage (ICH) have reported conflicting results. We here performed a meta-analysis based on the evidence currently available from the literature to make a more precise estimation of this relationship. Methods: Published literature from the National Library of Medline and Embase databases were retrieved. Odds ratio (OR) and 95% confidence interval (CI) were calculated in fixed- or random-effects models when appropriate. Subgroup analyses were performed by race. Results: This meta-analysis included 11 case-control studies, which included 1,238 ICH cases and 3,575 controls. The combined results based on all studies showed that ICH cases had a significantly higher frequency of APOE ε4 allele (OR= 1.42, 95% CI= 1.21,1.67, P<0.001). In the subgroup analysis by race, we also found that ICH cases had a significantly higher frequency of APOE ε4 allele in Asians (OR= 1.52, 95% CI= 1.20,1.93, P<0.001) and in Caucasians (OR= 1.34, 95% CI= 1.07,1.66, P=0.009). There was no significant relationship between APOE ε2 allele and the risk of ICH. Conclusion: Our meta-analysis suggested that APOE ε4 allele was associated with a higher risk of ICH.
- Subjects
APOLIPOPROTEIN E; GENETIC polymorphisms; CEREBRAL hemorrhage; APOLIPOPROTEINS; POPULATION genetics
- Publication
Lipids in Health & Disease, 2014, Vol 13, Issue 1, p1
- ISSN
1476-511X
- Publication type
Article
- DOI
10.1186/1476-511X-13-47