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- Title
Aseptic meningitis in Germany associated with echovirus type 13.
- Authors
Diedrich, Sabine; Schreier, Eckart; Diedrich, S; Schreier, E
- Abstract
<bold>Background: </bold>Echoviruses are the commonest cause of aseptic meningitis. Echovirus type 13 which has not been isolated in Germany over a long period of time was the predominant enterovirus serotype associated with different local outbreaks of aseptic meningitis in Germany in 2000.<bold>Methods: </bold>Virus isolation was performed from cerebrospinal fluid and stools. In order to study the genetic relationship of echovirus type 13 isolates, sequence analysis of a part of VP1 (~300 nt) was carried out. Isolates from different geographic regions were compared to each other as well as to elder viruses (prototype strain from 1953, four isolates from 1965-1986).<bold>Results: </bold>Overall, 55 isolates of echovirus type 13 were obtained from different parts of Germany. It was shown that the new isolated strains have a very high degree of homology on the nucleotide level (> 98%)) but differ significantly from the old strains (76-85%).<bold>Conclusions: </bold>a) Rare enterovirus serotypes can cause serious illness.b) The molecular drift has also been shown for other enterovirus serotypes.
- Subjects
GERMANY; MENINGITIS; ECHO viruses; VIRUS isolation; GENETICS
- Publication
BMC Infectious Diseases, 2001, Vol 1, Issue 1, p14
- ISSN
1471-2334
- Publication type
journal article
- DOI
10.1186/1471-2334-1-14