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- Title
Elevated exhaled acetone concentration in stage C heart failure patients with diabetes mellitus.
- Authors
Tetsuro Yokokawa; Takamasa Sato; Satoshi Suzuki; Masayoshi Oikawa; Akiomi Yoshihisa; Atsushi Kobayashi; Takayoshi Yamaki; Hiroyuki Kunii; Kazuhiko Nakazato; Hitoshi Suzuki; Shu-ichi Saitoh; Takafumi Ishida; Akito Shimouchi; Yasuchika Takeishi; Yokokawa, Tetsuro; Sato, Takamasa; Suzuki, Satoshi; Oikawa, Masayoshi; Yoshihisa, Akiomi; Kobayashi, Atsushi
- Abstract
<bold>Background: </bold>Breath acetone is a noninvasive biomarker of heart failure; however, its significance in heart failure patients with diabetes mellitus has yet to be clarified. The objective of this study is to investigate whether exhaled acetone concentration is a noninvasive biomarker in heart failure patients with diabetes mellitus.<bold>Methods: </bold>This study prospectively included 35 diabetic patients with stage C heart failure and 20 diabetic patients with or at risk of heart failure (stage A or B). Exhaled breath was collected after an overnight fast.<bold>Results: </bold>The stage C group had significantly higher brain natriuretic peptide levels, larger left ventricular diameter, lower left ventricular ejection fraction, and more frequent use of β-blocker, compared with the stage A or B group. The stage C group had higher exhaled acetone concentrations than the stage A or B group (p = 0.013). Exhaled acetone concentration was correlated with total ketone bodies (r = 0.588, p < 0.001) and brain natriuretic peptide (r = 0.415, p = 0.002).<bold>Conclusion: </bold>Stage C heart failure patients with diabetes mellitus have elevated exhaled acetone concentrations. Exhaled acetone concentration could be a noninvasive biomarker in heart failure patients with diabetes mellitus.
- Subjects
ACETONE; HEART failure; PEOPLE with diabetes; VENTRICULAR ejection fraction; ENERGY metabolism
- Publication
BMC Cardiovascular Disorders, 2017, Vol 17, p1
- ISSN
1471-2261
- Publication type
journal article
- DOI
10.1186/s12872-017-0713-0