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- Title
Mechanisms and Treatment for Cancer- and Chemotherapy-Related Cognitive Impairment in Survivors of Non-CNS Malignancies.
- Authors
Ni-Chun Chung; Walker, Adam K.; Dhillon, Haryana M.; Vardy, Janette L.
- Abstract
Up to 70% of survivors of adult-onset, non--central nervous system (CNS) solid tumors report cognitive symptoms, and approximately 30% have impairment on formal neuropsychological testing. The etiology of the impairment is unknown. There is a lack of robust evidence on how to prevent or treat cancer-related cognitive impairment (CRCI). Here, we review the evidence for the putative mechanisms of CRCI by examining clinical and preclinical models, primarily those associated with chemotherapy. Pharmacologic and nonpharmacologic options for treating CRCI are discussed based on the best evidence available. Practical clinical advice for health professionals managing patients with CRCI is also provided.
- Subjects
COGNITION disorders diagnosis; COGNITION disorders treatment; CANCER chemotherapy; CANCER patient psychology; CENTRAL nervous system tumors; COGNITION disorders; NEUROPSYCHOLOGICAL tests; DISEASE complications; PREVENTION
- Publication
Oncology (08909091), 2018, Vol 32, Issue 12, p591
- ISSN
0890-9091
- Publication type
Article