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Human inborn errors of long‐chain fatty acid oxidation show impaired inflammatory responses to TLR4‐ligand LPS.
Published in:
FASEB Bioadvances, 2024, v. 6, n. 9, p. 337, doi. 10.1096/fba.2024-00060
By:
- Mosegaard, Signe;
- Twayana, Krishna S.;
- Denis, Simone W.;
- Kroon, Jeffrey;
- Schomakers, Bauke V.;
- van Weeghel, Michel;
- Houtkooper, Riekelt H.;
- Olsen, Rikke K. J.;
- Holm, Christian K.
Publication type:
Article
A metabolomic signature of decelerated physiological aging in human plasma.
Published in:
GeroScience, 2023, v. 45, n. 6, p. 3147, doi. 10.1007/s11357-023-00827-0
By:
- Janssens, Georges E.;
- Grevendonk, Lotte;
- Schomakers, Bauke V.;
- Perez, Ruben Zapata;
- van Weeghel, Michel;
- Schrauwen, Patrick;
- Hoeks, Joris;
- Houtkooper, Riekelt H.
Publication type:
Article
Gallstone Formation Follows a Different Trajectory in Bariatric Patients Compared to Nonbariatric Patients.
Published in:
Metabolites (2218-1989), 2021, v. 11, n. 10, p. 682, doi. 10.3390/metabo11100682
By:
- Haal, Sylke;
- Guman, Maimoena S. S.;
- Acherman, Yair I. Z.;
- Jansen, Johannes P. G.;
- van Weeghel, Michel;
- van Lenthe, Henk;
- Wever, Eric J. M.;
- Gerdes, Victor E. A.;
- Voermans, Rogier P.;
- Groen, Albert K.
Publication type:
Article
Succinate Is an Inflammation-Induced Immunoregulatory Metabolite in Macrophages.
Published in:
Metabolites (2218-1989), 2020, v. 10, n. 9, p. 372, doi. 10.3390/metabo10090372
By:
- Harber, Karl J.;
- de Goede, Kyra E.;
- Verberk, Sanne G. S.;
- Meinster, Elisa;
- de Vries, Helga E.;
- van Weeghel, Michel;
- de Winther, Menno P. J.;
- Van den Bossche, Jan
Publication type:
Article
Identification of Metabolic Biomarkers in Relation to Methotrexate Response in Early Rheumatoid Arthritis.
Published in:
Journal of Personalized Medicine, 2020, v. 10, n. 4, p. 271, doi. 10.3390/jpm10040271
By:
- Gosselt, Helen R.;
- Muller, Ittai B.;
- Jansen, Gerrit;
- van Weeghel, Michel;
- Vaz, Frédéric M.;
- Hazes, Johanna M. W.;
- Heil, Sandra G.;
- de Jonge, Robert
Publication type:
Article
Development and application of a UHPLC-MS/MS metabolomics based comprehensive systemic and tissue-specific screening method for inflammatory, oxidative and nitrosative stress.
Published in:
Analytical & Bioanalytical Chemistry, 2018, v. 410, n. 10, p. 2551, doi. 10.1007/s00216-018-0912-2
By:
- Schoeman, Johannes C.;
- Harms, Amy C.;
- van Weeghel, Michel;
- Berger, Ruud;
- Vreeken, Rob J.;
- Hankemeier, Thomas
Publication type:
Article
Ribosomal protein gene RPL9 variants can differentially impair ribosome function and cellular metabolism.
Published in:
Nucleic Acids Research, 2020, v. 48, n. 2, p. 770, doi. 10.1093/nar/gkz1042
By:
- Lezzerini, Marco;
- Penzo, Marianna;
- O'Donohue, Marie-Françoise;
- Marques dos Santos Vieira, Carolina;
- Saby, Manon;
- Elfrink, Hyung L;
- Diets, Illja J;
- Hesse, Anne-Marie;
- Couté, Yohann;
- Gastou, Marc;
- Nin-Velez, Alexandra;
- Nikkels, Peter G J;
- Olson, Alexandra N;
- Zonneveld-Huijssoon, Evelien;
- Jongmans, Marjolijn C J;
- Zhang, GuangJun;
- van Weeghel, Michel;
- Houtkooper, Riekelt H;
- Wlodarski, Marcin W;
- Kuiper, Roland P
Publication type:
Article
Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism.
Published in:
Nature Communications, 2020, v. 11, p. 1, doi. 10.1038/s41467-020-14811-1
By:
- Loregger, Anke;
- Raaben, Matthijs;
- Nieuwenhuis, Joppe;
- Tan, Josephine M. E.;
- Jae, Lucas T.;
- van den Hengel, Lisa G.;
- Hendrix, Sebastian;
- van den Berg, Marlene;
- Scheij, Saskia;
- Ji-Ying Song;
- Huijbers, Ivo J.;
- Kroese, Lona J.;
- Ottenhoff, Roelof;
- van Weeghel, Michel;
- van de Sluis, Bart;
- Brummelkamp, Thijn;
- Zelcer, Noam
Publication type:
Article
Increased cardiac fatty acid oxidation in a mouse model with decreased malonyl-CoA sensitivity of CPT1B.
Published in:
Cardiovascular Research, 2018, v. 114, n. 10, p. 1324, doi. 10.1093/cvr/cvy089
By:
- Weeghel, Michel van;
- Abdurrachim, Desiree;
- Nederlof, Rianne;
- Argmann, Carmen A;
- Houtkooper, Riekelt H;
- Hagen, Jacob;
- Nabben, Miranda;
- Denis, Simone;
- Ciapaite, Jolita;
- Kolwicz, Stephen C
Publication type:
Article
Food withdrawal lowers energy expenditure and induces inactivity in long-chain fatty acid oxidation-deficient mouse models.
Published in:
FASEB Journal, 2014, v. 28, n. 7, p. 2891, doi. 10.1096/fj.14-250241
By:
- Diekman, Eugene F.;
- van Weeghel, Michel;
- Wanders, Ronald J. A.;
- Visser, Gepke;
- Houten, Sander M.
Publication type:
Article
Identification and characterization of Eci3, a murine kidney-specific Δ³, Δ²-enoyl-CoA isomerase.
Published in:
FASEB Journal, 2014, v. 28, n. 3, p. 1365, doi. 10.1096/fj.13-240416
By:
- van Weeghel, Michel;
- Ofman, Rob;
- Argmann, Carmen A.;
- Ruiter, Jos P. N.;
- Claessen, Nike;
- Oussoren, Saskia V.;
- Wanders, Ronald J. A.;
- Aten, Jan;
- Houten, Sander M.
Publication type:
Article
Functional redundancy of mitochondrial enoyl-CoA isomerases in the oxidation of unsaturated fatty acids.
Published in:
FASEB Journal, 2012, v. 26, n. 10, p. 4316, doi. 10.1096/fj.12-206326
By:
- Van Weeghel, Michel;
- Te Brinke, Heleen;
- Van Lenthe, Henk;
- Kulik, Wim;
- Minkler, Paul E.;
- Stoll, Maria S. K.;
- Sass, Jorn Oliver;
- Janssen, Uwe;
- Stoffel, Wilhelm;
- Schwab, K. Otfried;
- Wanders, Ronald J. A.;
- Hoppel, Charles L.;
- Houten, Sander M.
Publication type:
Article
The Plasma Lipidomic Landscape in Patients with Sepsis due to Community-acquired Pneumonia.
Published in:
American Journal of Respiratory & Critical Care Medicine, 2024, v. 209, n. 8, p. 973, doi. 10.1164/rccm.202308-1321OC
By:
- Chouchane, Osoul;
- Schuurman, Alex R.;
- Reijnders, Tom D. Y.;
- Peters-Sengers, Hessel;
- Butler, Joe M.;
- Uhel, Fabrice;
- Schultz, Marcus J.;
- Bonten, Marc J.;
- Cremer, Olaf L.;
- Calfee, Carolyn S.;
- Matthay, Michael A.;
- Langley, Raymond J.;
- Alipanah-Lechner, Narges;
- Kingsmore, Stephen F.;
- Rogers, Angela;
- van Weeghel, Michel;
- Vaz, Frédéric M.;
- van der Poll, Tom
Publication type:
Article
Ophthalmic acid is a glutathione regulating tripeptide.
Published in:
FEBS Journal, 2024, v. 291, n. 15, p. 3317, doi. 10.1111/febs.17061
By:
- Schomakers, Bauke V.;
- Jillings, Sonia L.;
- van Weeghel, Michel;
- Vaz, Frédéric M.;
- Salomons, Gajja S.;
- Janssens, Georges E.;
- Houtkooper, Riekelt H.
Publication type:
Article
HIF-1α Stabilization in Flagellin-Stimulated Human Bronchial Cells Impairs Barrier Function.
Published in:
Cells (2073-4409), 2022, v. 11, n. 3, p. 391, doi. 10.3390/cells11030391
By:
- Ramirez-Moral, Ivan;
- Ferreira, Bianca L.;
- Butler, Joe M.;
- van Weeghel, Michel;
- Otto, Natasja A.;
- de Vos, Alex F.;
- Yu, Xiao;
- de Jong, Menno D.;
- Houtkooper, Riekelt H.;
- van der Poll, Tom
Publication type:
Article
The effect of mirabegron on energy expenditure and brown adipose tissue in healthy lean South Asian and Europid men.
Published in:
Diabetes, Obesity & Metabolism, 2020, v. 22, n. 11, p. 2032, doi. 10.1111/dom.14120
By:
- Nahon, Kimberly J.;
- Janssen, Laura G. M.;
- Sardjoe Mishre, Aashley S. D.;
- Bilsen, Manu P.;
- van der Eijk, Jari A.;
- Botani, Kani;
- Overduin, Lisanne A.;
- Ruiz, Jonatan R.;
- Burakiewicz, Jedrzej;
- Dzyubachyk, Oleh;
- Webb, Andrew G.;
- Kan, Hermien E.;
- Berbée, Jimmy F. P.;
- van Klinken, Jan-Bert;
- van Dijk, Ko Willems;
- van Weeghel, Michel;
- Vaz, Frédéric M.;
- Coskun, Tamer;
- Jazet, Ingrid M.;
- Kooijman, Sander
Publication type:
Article
Disease progression in women with X-linked adrenoleukodystrophy is slow.
Published in:
2019
By:
- Huffnagel, Irene C.;
- Dijkgraaf, Marcel G. W.;
- Janssens, Georges E.;
- van Weeghel, Michel;
- van Geel, Björn M.;
- Poll-The, Bwee Tien;
- Kemp, Stephan;
- Engelen, Marc
Publication type:
journal article
Profiling of intracellular metabolites produced from galactose and its potential for galactosemia research.
Published in:
2018
By:
- van Weeghel, Michel;
- Welling, Lindsey;
- Treacy, Eileen P.;
- Wanders, Ronald J. A.;
- Ferdinandusse, Sacha;
- Bosch, Annet M.
Publication type:
journal article
Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-20141-z
By:
- Baardman, Jeroen;
- Verberk, Sanne G. S.;
- van der Velden, Saskia;
- Gijbels, Marion J. J.;
- van Roomen, Cindy P. P. A.;
- Sluimer, Judith C.;
- Broos, Jelle Y.;
- Griffith, Guillermo R.;
- Prange, Koen H. M.;
- van Weeghel, Michel;
- Lakbir, Soufyan;
- Molenaar, Douwe;
- Meinster, Elisa;
- Neele, Annette E.;
- Kooij, Gijs;
- de Vries, Helga E.;
- Lutgens, Esther;
- Wellen, Kathryn E.;
- de Winther, Menno P. J.;
- Van den Bossche, Jan
Publication type:
Article
The influence of neuronal electrical activity on the mammalian central clock metabolome.
Published in:
Metabolomics, 2018, v. 14, n. 10, p. 1, doi. 10.1007/s11306-018-1423-z
By:
- Buijink, M. Renate;
- van Weeghel, Michel;
- Gülersönmez, M. Can;
- Harms, Amy C.;
- Rohling, Jos H. T.;
- Meijer, Johanna H.;
- Hankemeier, Thomas;
- Michel, Stephan
Publication type:
Article
Smoking cessation only partially reverses cardiac metabolic and structural remodeling in mice.
Published in:
Acta Physiologica, 2024, v. 240, n. 7, p. 1, doi. 10.1111/apha.14145
By:
- Aid, Jekaterina;
- Tanjeko, Ajime Tom;
- Serré, Jef;
- Eggelbusch, Moritz;
- Noort, Wendy;
- de Wit, Gerard M. J.;
- van Weeghel, Michel;
- Puurand, Marju;
- Tepp, Kersti;
- Gayan‐Ramirez, Ghislaine;
- Degens, Hans;
- Käämbre, Tuuli;
- Wüst, Rob C. I.
Publication type:
Article
Human ovarian aging is characterized by oxidative damage and mitochondrial dysfunction.
Published in:
Human Reproduction, 2023, v. 38, n. 11, p. 2208, doi. 10.1093/humrep/dead177
By:
- Smits, Myrthe A J;
- Schomakers, Bauke V;
- Weeghel, Michel van;
- Wever, Eric J M;
- Wüst, Rob C I;
- Dijk, Frederike;
- Janssens, Georges E;
- Goddijn, Mariëtte;
- Mastenbroek, Sebastiaan;
- Houtkooper, Riekelt H;
- Hamer, Geert
Publication type:
Article
Reduced ech-6 expression attenuates fat-induced lifespan shortening in C. elegans.
Published in:
Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-07397-9
By:
- Liu, Yasmine J.;
- Gao, Arwen W.;
- Smith, Reuben L.;
- Janssens, Georges E.;
- Panneman, Daan M.;
- Jongejan, Aldo;
- van Weeghel, Michel;
- Vaz, Frédéric M.;
- Silvestrini, Melissa J.;
- Lapierre, Louis R.;
- MacInnes, Alyson W.;
- Houtkooper, Riekelt H.
Publication type:
Article
NLRX1 Deletion Increases Ischemia-Reperfusion Damage and Activates Glucose Metabolism in Mouse Heart.
Published in:
Frontiers in Immunology, 2020, v. 11, p. N.PAG, doi. 10.3389/fimmu.2020.591815
By:
- Zhang, Hong;
- Xiao, Yang;
- Nederlof, Rianne;
- Bakker, Diane;
- Zhang, Pengbo;
- Girardin, Stephen E.;
- Hollmann, Markus W.;
- Weber, Nina C.;
- Houten, Sander M.;
- van Weeghel, Michel;
- Kibbey, Richard G.;
- Zuurbier, Coert J.
Publication type:
Article
Muscle abnormalities worsen after post-exertional malaise in long COVID.
Published in:
Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-023-44432-3
By:
- Appelman, Brent;
- Charlton, Braeden T.;
- Goulding, Richie P.;
- Kerkhoff, Tom J.;
- Breedveld, Ellen A.;
- Noort, Wendy;
- Offringa, Carla;
- Bloemers, Frank W.;
- van Weeghel, Michel;
- Schomakers, Bauke V.;
- Coelho, Pedro;
- Posthuma, Jelle J.;
- Aronica, Eleonora;
- Joost Wiersinga, W.;
- van Vugt, Michèle;
- Wüst, Rob C. I.
Publication type:
Article
Riboflavin-responsive oxidative phosphorylation complex I deficiency caused by defective ACAD9: new function for an old gene.
Published in:
Brain: A Journal of Neurology, 2011, v. 134, n. 1, p. 210, doi. 10.1093/brain/awq273
By:
- Gerards, Mike;
- van den Bosch, Bianca J. C.;
- Danhauser, Katharina;
- Serre, Valérie;
- van Weeghel, Michel;
- Wanders, Ronald J. A.;
- Nicolaes, Gerry A. F.;
- Sluiter, Wim;
- Schoonderwoerd, Kees;
- Scholte, Hans R.;
- Prokisch, Holger;
- Rötig, Agnès;
- de Coo, Irenaeus F. M.;
- Smeets, Hubert J. M.
Publication type:
Article
Multi‐omics in classical galactosemia: Evidence for the involvement of multiple metabolic pathways.
Published in:
Journal of Inherited Metabolic Disease, 2022, v. 45, n. 6, p. 1094, doi. 10.1002/jimd.12548
By:
- Hermans, Merel E.;
- van Weeghel, Michel;
- Vaz, Frédéric M.;
- Ferdinandusse, Sacha;
- Hollak, Carla E. M.;
- Huidekoper, Hidde H.;
- Janssen, Mirian C. H.;
- van Kuilenburg, André B. P.;
- Pras‐Raves, Mia L.;
- Wamelink, Mirjam M. C.;
- Wanders, Ronald J. A.;
- Welsink‐Karssies, Mendy M.;
- Bosch, Annet M.
Publication type:
Article
Loss of temporal coherence in the circadian metabolome across multiple tissues during ageing in mice.
Published in:
European Journal of Neuroscience, 2024, v. 60, n. 2, p. 3843, doi. 10.1111/ejn.16428
By:
- Buijink, M. Renate;
- van Weeghel, Michel;
- Harms, Amy;
- Murli, Devika S.;
- Meijer, Johanna H.;
- Hankemeier, Thomas;
- Michel, Stephan;
- Kervezee, Laura
Publication type:
Article
Effects of Light-at-Night on the Rat Liver – A Role for the Autonomic Nervous System.
Published in:
Frontiers in Neuroscience, 2019, p. N.PAG, doi. 10.3389/fnins.2019.00647
By:
- Opperhuizen, Anne-Loes;
- Foppen, Ewout;
- Jonker, Martijs;
- Wackers, Paul;
- van Faassen, Martijn;
- van Weeghel, Michel;
- van Kerkhof, Linda;
- Fliers, Eric;
- Kalsbeek, Andries
Publication type:
Article
Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion.
Published in:
PLoS Genetics, 2019, v. 15, n. 3, p. 1, doi. 10.1371/journal.pgen.1007633
By:
- Liu, Yasmine J.;
- Janssens, Georges E.;
- McIntyre, Rebecca L.;
- Molenaars, Marte;
- Kamble, Rashmi;
- Gao, Arwen W.;
- Jongejan, Aldo;
- Weeghel, Michel van;
- MacInnes, Alyson W.;
- Houtkooper, Riekelt H.
Publication type:
Article
Sitting less elicits metabolic responses similar to exercise and enhances insulin sensitivity in postmenopausal women.
Published in:
Diabetologia, 2021, v. 64, n. 12, p. 2817, doi. 10.1007/s00125-021-05558-5
By:
- Remie, Carlijn M. E.;
- Janssens, Georges E.;
- Bilet, Lena;
- van Weeghel, Michel;
- Duvivier, Bernard M. F. M.;
- de Wit, Vera H. W.;
- Connell, Niels J.;
- Jörgensen, Johanna A.;
- Schomakers, Bauke V.;
- Schrauwen-Hinderling, Vera B.;
- Hoeks, Joris;
- Hesselink, Matthijs K. C.;
- Phielix, Esther;
- Houtkooper, Riekelt H.;
- Schrauwen, Patrick
Publication type:
Article
Lipidomics in Non-alcoholic Fatty Liver Disease: Exploring Serum Lipids as Biomarkers for Pediatric NAFLD.
Published in:
2020
By:
- Draijer, Laura G.;
- Froon-Torenstra, Denise;
- van Weeghel, Michel;
- Vaz, Frédéric M.;
- Bohte, Anneloes E.;
- Holleboom, Adriaan G.;
- Benninga, Marc A.;
- Koot, Bart G. P.
Publication type:
journal article
Aging selectively dampens oscillation of lipid abundance in white and brown adipose tissue.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-85455-4
By:
- Held, Ntsiki M.;
- Buijink, M. Renate;
- Elfrink, Hyung L.;
- Kooijman, Sander;
- Janssens, Georges E.;
- Luyf, Angela C. M.;
- Pras-Raves, Mia L.;
- Vaz, Frédéric M.;
- Michel, Stephan;
- Houtkooper, Riekelt H.;
- van Weeghel, Michel
Publication type:
Article
Time‐restricted feeding during the inactive phase abolishes the daily rhythm in mitochondrial respiration in rat skeletal muscle.
Published in:
FASEB Journal, 2022, v. 36, n. 2, p. 1, doi. 10.1096/fj.202100707R
By:
- de Goede, Paul;
- Wüst, Rob C. I.;
- Schomakers, Bauke V.;
- Denis, Simone;
- Vaz, Frédéric M.;
- Pras‐Raves, Mia L.;
- van Weeghel, Michel;
- Yi, Chun‐Xia;
- Kalsbeek, Andries;
- Houtkooper, Riekelt H.
Publication type:
Article
Circadian misalignment disturbs the skeletal muscle lipidome in healthy young men.
Published in:
FASEB Journal, 2021, v. 35, n. 6, p. 1, doi. 10.1096/fj.202100143R
By:
- Harmsen, Jan-Frieder;
- van Polanen, Nynke;
- van Weeghel, Michel;
- Wefers, Jakob;
- Hoeks, Joris;
- Vaz, Frédéric M.;
- Pras-Raves, Mia L.;
- van Kampen, Antoine H. C.;
- Schaart, Gert;
- van Moorsel, Dirk;
- Hansen, Jan;
- Hesselink, Matthijs K. C.;
- Houtkooper, Riekelt H.;
- Schrauwen, Patrick
Publication type:
Article
Reduced nicotinamide mononucleotide is a new and potent NAD+ precursor in mammalian cells and mice.
Published in:
FASEB Journal, 2021, v. 35, n. 4, p. 1, doi. 10.1096/fj.202001826R
By:
- Zapata-Pérez, Rubén;
- Tammaro, Alessandra;
- Schomakers, Bauke V.;
- Scantlebery, Angelique M. L.;
- Denis, Simone;
- Elfrink, Hyung L.;
- Giroud-Gerbetant, Judith;
- Cantó, Carles;
- López-Leonardo, Carmen;
- McIntyre, Rebecca L.;
- van Weeghel, Michel;
- Sánchez-Ferrer, Álvaro;
- Houtkooper, Riekelt H.
Publication type:
Article
The Antibiotic Doxycycline Impairs Cardiac Mitochondrial and Contractile Function.
Published in:
International Journal of Molecular Sciences, 2021, v. 22, n. 8, p. 4100, doi. 10.3390/ijms22084100
By:
- Wüst, Rob C. I.;
- Coolen, Bram F.;
- Held, Ntsiki M.;
- Daal, Mariah R. R.;
- Alizadeh Tazehkandi, Vida;
- Baks-te Bulte, Luciënne;
- Wiersma, Marit;
- Kuster, Diederik W. D.;
- Brundel, Bianca J. J. M.;
- van Weeghel, Michel;
- Strijkers, Gustav J.;
- Houtkooper, Riekelt H.
Publication type:
Article
Metabolic rerouting via SCD1 induction impacts X-linked adrenoleukodystrophy.
Published in:
2021
By:
- Raas, Quentin;
- van de Beek, Malu-Clair;
- Forss-Petter, Sonja;
- Dijkstra, Inge M. E.;
- Deschiffart, Abigail;
- Freshner, Briana C.;
- Stevenson, Tamara J.;
- Jaspers, Yorrick R. J.;
- Nagtzaam, Liselotte;
- Wanders, Ronald J. A.;
- van Weeghel, Michel;
- Joo-Yeon Engelen-Lee;
- Engelen, Marc;
- Eichler, Florian;
- Berger, Johannes;
- Bonkowsky, Joshua L.;
- Kemp, Stephan;
- Dijkstra, Inge Me;
- Jaspers, Yorrick Rj;
- Nagtzaam, Liselotte M
Publication type:
journal article

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