We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Improvement of Airflow Distribution and Contamination Control for a Biotech Cleanroom.
- Authors
Wang, Fujen; Permana, Indra; Lee, Kwowhei; Rakshit, Dibakar; Rosulindo, Parisya Premiera
- Abstract
The biotech cleanroom industry presents a biological basis for living organisms or their components (bacteria or enzymes) to produce helpful medicine. However, biotech industries such as vaccine production need a clean critical environment and contamination control that is always a vital concern for the manufacturing process. This study investigates a biotech cleanroom through a comprehensive field measurement and numerical simulation. The field measurement test results conformed to the design specification to satisfactorily meet with the cleanroom standard of PIC/S and EU GMP. Furthermore, the field measurement data were used as a basic validation and boundary condition for numerical simulation. The numerical simulation results revealed that the concentration distribution in case 1 as a baseline case showed satisfactory results, with a removal efficiency of 75.2% and ventilation efficiency of 80%. However, there was still a high concentration accumulated in certain areas. The improvement strategy was analyzed through non-unidirectional flow ventilation with different face velocities and by adding one return air grille for case 2 and two return air grilles for case 3. The results revealed that case 2 presented the best results in this study, with a removal efficiency of 86.7% and ventilation efficiency of 82% when supplying air velocity at 0.2 m/s. In addition, increasing the supply air velocity to 0.3 m/s could enhance removal ventilation by around 19% and ventilation efficiency by around 5%.
- Subjects
AIR flow; BACTERIAL enzymes; POLLUTION; VENTILATION; VACCINES industry; AIRDROP
- Publication
Atmosphere, 2022, Vol 13, Issue 2, p335
- ISSN
2073-4433
- Publication type
Article
- DOI
10.3390/atmos13020335