We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Advanced Continuous Flow Platform for On-Demand Pharmaceutical Manufacturing.
- Authors
Ping Zhang; Weeranoppanant, Nopphon; Thomas, Dale A.; Kohei Tahara; Stelzer, Torsten; Russell, Mary Grace; O’Mahony, Marcus; Myerson, Allan S.; Hongkun Lin; Kelly, Liam P.; Jensen, Klavs F.; Jamison, Timothy F.; Chunhui Dai; Yuqing Cui; Briggs, Naomi; Beingessner, Rachel L.; Adamo, Andrea
- Abstract
As a demonstration of an alternative to the challenges faced with batch pharmaceutical manufacturing including the large production footprint and lengthy timescale, we previously reported a refrigerator-sized continuous flow system for the on-demand production of essential medicines. Building on this technology, herein we report a second-generation, reconfigurable and 25% smaller (by volume) continuous flow pharmaceutical manufacturing platform featuring advances in reaction and purification equipment. Consisting of two compact [0.7 (L) Χ 0.5 (D) Χ 1.3m (H)] stand-alone units for synthesis and purification/ formulation processes, the capabilities of this automated system are demonstrated with the synthesis of nicardipine hydrochloride and the production of concentrated liquid doses of ciprofloxacin hydrochloride, neostigmine methylsulfate and rufinamide that meet US Pharmacopeia standards.
- Subjects
CHLORIDES; SULFATES; CIPROFLOXACIN; CHEMICAL engineering; CHEMICAL synthesis
- Publication
Chemistry - A European Journal, 2018, Vol 24, Issue 11, p2776
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201706004