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- Title
ISCEV extended protocol for the photopic On-Off ERG.
- Authors
Sustar, Maja; Holder, Graham E.; Kremers, Jan; Barnes, Claire S.; Lei, Bo; Khan, Naheed W.; Robson, Anthony G.
- Abstract
The International Society for Clinical Electrophysiology of Vision (ISCEV) standard for full-field electroretinography (ERG) describes a minimum procedure, but encourages more extensive testing. This ISCEV extended protocol describes an extension to the ERG standard, namely the photopic On-Off ERG, and outlines common clinical applications. A light stimulus duration of 150-200 ms is used in the presence of a rod-suppressing background to elicit cone-driven On- and Off-system ERG components. The On-response occurs after the stimulus onset and has a negative a-wave and positive b-wave. The Off d-wave is a positive component evoked by stimulus offset. Common diagnoses that may benefit from additional photopic On-Off ERG testing include retinal dystrophies and retinal disorders that cause dysfunction at a level that is post-phototransduction or post-receptoral. On-Off ERGs assess the relative involvement of On- and Off-systems and may be of use in the diagnosis of disorders such as complete and incomplete congenital stationary night blindness (complete and incomplete CSNB), melanoma-associated retinopathy, and some forms of autoimmune retinopathy. The photopic On-Off ERGs may also be useful in X-linked retinoschisis, Batten disease, Duchenne muscular dystrophy, spinocerebellar degeneration, quinine toxicity, and other retinal disorders.
- Subjects
ELECTRORETINOGRAPHY; DIABETIC retinopathy; BIPOLAR cells; RETINA abnormalities; NIGHT blindness; FRIEDREICH'S ataxia
- Publication
Documenta Ophthalmologica, 2018, Vol 136, Issue 3, p199
- ISSN
0012-4486
- Publication type
Article
- DOI
10.1007/s10633-018-9645-y