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- Title
Low vitamin D is associated with diabetes peripheral neuropathy in older but not in young and middle-aged patients.
- Authors
Niu, Yang; Li, Ji; Peng, Rongxia; Zhao, Xuelin; Wu, Jiang; Tang, Qingya
- Abstract
<bold>Background: </bold>The relationship between vitamin D and diabetes peripheral neuropathy (DPN) is not consistent among epidemiologic studies. Thus, we aimed to investigate this relationship in different age groups.<bold>Methods: </bold>In this cross-sectional study, 1461 patients admitted to the Department of Endocrinology at Xinhua Hospital from June 2016 to September 2017 were divided into three age groups: a Youth group (24-44 years, n = 127), a Middle-age group (45-64 years, n = 779), and an Elderly group (≥65 years, n = 555). Basic information and laboratory results were collected from medical records.<bold>Results: </bold>Among the patients, 32.72% had DPN, with 12.59% in the Youth group, 33.63% in the Middle-age group, and 36.04% in the Elderly group. For the total sample and the Elderly group, serum 25(OH)D concentrations in DPN patients were lower than in non-DPN patients (P < .05). The results of multivariate logistic regression indicated a low vitamin D concentration to be a risk factor for DPN in the Elderly group (P < .05), but such relationship was not found in the Youth or Middle-age groups. Moreover, according to ROC analysis, a serum 25(OH)D level < 34.87 nmol/L suggests the occurrence of DPN in elderly patients with type 2 diabetes (P < .001).<bold>Conclusions: </bold>This study is the first to report that a low vitamin D level is associated with DPN in diabetic patients over 65 years of age and might be used as a predictor of DPN in this population. The interaction between vitamin D and age in the development of DPN and its underlying mechanisms need to be further explored.
- Subjects
VITAMIN D; PERIPHERAL neuropathy; TYPE 2 diabetes; AGE groups; DIABETES; BLOOD sugar analysis; VITAMINS; RESEARCH; DIABETIC neuropathies; CROSS-sectional method; RESEARCH methodology; PROGNOSIS; EVALUATION research; MEDICAL cooperation; COMPARATIVE studies; VITAMIN D deficiency; RECEIVER operating characteristic curves; LONGITUDINAL method; DISEASE complications
- Publication
Diabetes/Metabolism Research & Reviews, 2019, Vol 35, Issue 6, pN.PAG
- ISSN
1520-7552
- Publication type
journal article
- DOI
10.1002/dmrr.3162