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- Title
Synthesis and Anticancer Activity of Podophyllotoxin Derivatives.
- Authors
Lin, K.; Zhang, X.; Dai, X.; Ma, L.; Bozorov, K.; Guo, H.; Huang, G.; Cao, J.
- Abstract
Two series of podophyllotoxin derivatives were synthesized by addition of a 4β-sulfanilamide to or substitution of a 4β-amide into podophyllotoxin. Their cytotoxicities were evaluated against four human cancer cell lines (A549, HeLa, MCF-7, and PC-3). Investigations of the structure–activity relationship were generalized. Derivative 9f (2-thienoylaminoepipodophyllotoxin) exhibited the highest activity against the cancer cells, inhibiting growth of MCF-7 cells with IC50 0.67 ± 0.37 μM. A change in the morphology of MCF-7 cells treated with 9f also confirmed its activity as a cytotoxic derivative against cancer cells.
- Subjects
ANTINEOPLASTIC agents; PODOPHYLLOTOXIN; CELL morphology; STRUCTURE-activity relationships; CANCER cells; AMIDE derivatives
- Publication
Chemistry of Natural Compounds, 2021, Vol 57, Issue 6, p1010
- ISSN
0009-3130
- Publication type
Article
- DOI
10.1007/s10600-021-03539-z