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- Title
Synthesis and Cytotoxicity of Heterocyclic Amine Derivatives of Podophyllotoxin.
- Authors
Tian, Dan-li; Chen, Hong; Luo, Gang; Liang, Chun-po
- Abstract
A series of amine podophyllotoxin derivatives was designed and synthesized by aldehydes reacting with 4β-amino-desoxypodophyllotoxin or 4′-demethyldesoxypodophyllotoxin. The MTT assay was used to test the cytotoxic activity of 11 target compounds on HeLa cells and MCF-7 cells. All the compounds had varying degrees of antitumour activity in vitro. Several compounds showed improved activities against HeLa cells compared to that of the positive control etoposide (VP-16).
- Subjects
AMINE derivatives; PODOPHYLLOTOXIN; HELA cells; MULTIDRUG resistance; ETOPOSIDE; AROMATIC amines
- Publication
Chemistry of Natural Compounds, 2020, Vol 56, Issue 6, p994
- ISSN
0009-3130
- Publication type
Article
- DOI
10.1007/s10600-020-03265-y