A new dibenzocyclooctadiene lignan, longipedunin E (1), and a new natural product, benzoyl oxokadsuranol (2), together with seven known compounds 3-9, were isolated from the methanol extract of the stems of Kadsura longipedunculata. The structure elucidation of the new compound was primarily based on spectroscopic analyses including HR-ESI-MS, IR, UV, 1D and 2D NMR.