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- Title
Exploring the Remarkable Chemotherapeutic Potential of Polyphenolic Antioxidants in Battling Various Forms of Cancer.
- Authors
Imran, Mohammad; Insaf, Areeba; Hasan, Nazeer; Sugandhi, Vrushabh V.; Shrestha, Deumaya; Paudel, Keshav Raj; Jha, Saurav Kumar; Hansbro, Philip M.; Dua, Kamal; Devkota, Hari Prasad; Mohammed, Yousuf
- Abstract
Plant-derived compounds, specifically antioxidants, have played an important role in scavenging the free radicals present under diseased conditions. The persistent generation of free radicals in the body leads to inflammation and can result in even more severe diseases such as cancer. Notably, the antioxidant potential of various plant-derived compounds prevents and deregulates the formation of radicals by initiating their decomposition. There is a vast literature demonstrating antioxidant compounds' anti-inflammatory, anti-diabetic, and anti-cancer potential. This review describes the molecular mechanism of various flavonoids, such as quercetin, kaempferol, naringenin, epicatechin, and epicatechin gallate, against different cancers. Additionally, the pharmaceutical application of these flavonoids against different cancers using nanotechnologies such as polymeric, lipid-based nanoparticles (solid–lipid and liquid–lipid), liposomes, and metallic nanocarriers is addressed. Finally, combination therapies in which these flavonoids are employed along with other anti-cancer agents are described, indicating the effective therapies for the management of various malignancies.
- Subjects
EPICATECHIN; CATECHIN; CANCER chemotherapy; FREE radicals; RADICALS (Chemistry); ANTINEOPLASTIC agents; ANTIOXIDANTS
- Publication
Molecules, 2023, Vol 28, Issue 8, p3475
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules28083475