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- Title
Evaluation of Hepatosteatosis-Induced Increase in Fibrosity by Two-Dimensional Shear Wave Elastography in Children with Obesity and Comparison with Healthy Peers.
- Authors
Düzkalır, Hanife Gülden; Söbü, Elif; Aydıner, Ömer
- Abstract
Objective: The increase in the prevalence of obesity, nonalcoholic fatty liver disease (NAFLD), and related comorbidities in children creates a social and financial burden. In our study, we aimed to evaluate liver findings together with anthropometric and laboratory data with twodimensional shear wave elastography (2D-SWE), one of the SWE types, which is a noninvasive method for assessing tissue stiffness in children with obesity, and to obtain quantitative data that can be used in early diagnosis and follow-up. Materials and Methods: In our single-center, observational cross-sectional study, liver gray scale findings, 2D-SWE findings, anthropometric measurements, and laboratory values of 48 children with obesity and 50 healthy children aged between 5 and 18 years, both between groups and in prepubertal and pubertal subgroups, are compared. Results: A significant difference was found in the liver stiffness indicator kilopascal (kPA) values and between aspartate aminotransferase values in the prepubertal period and alanine aminotransferase values in the pubertal period (P < .001). No significant difference was found between insulin, HOMA-IR, waist circumference, waist/height ratio, and kPA. Conclusion: Two-dimensional shear wave elastography can be easily applied in the pediatric population as a practical, noninvasive, reproducible, and highly compatible technique. In this regard, 2D-SWE may be useful in the early diagnosis and follow-up of hepatosteatosis and fibrosis in children with obesity and NAFLD-risky cases.
- Subjects
TURKEY; STATISTICS; SCIENTIFIC observation; CHILDHOOD obesity; LIVER; ANTHROPOMETRY; CROSS-sectional method; NON-alcoholic fatty liver disease; FIBROSIS; CASE-control method; MANN Whitney U Test; FISHER exact test; COMPARATIVE studies; PEARSON correlation (Statistics); CHI-squared test; DATA analysis software; DATA analysis; ASPARTATE aminotransferase; ALANINE aminotransferase; DISEASE complications; CHILDREN
- Publication
Turkish Archives of Pediatrics, 2024, Vol 59, Issue 2, p205
- ISSN
2757-6256
- Publication type
Article
- DOI
10.5152/TurkArchPediatr.2024.23237