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- Title
Prospects of Optogenetic Prosthesis of the Degenerative Retina of the Eye.
- Authors
Ostrovsky, M. A.; Kirpichnikov, M. P.
- Abstract
The review discusses the prospects of using rhodopsin as an optogenetic tool for prosthetics of degenerative (blind) eye retina and the principles of optogenetic techniques. Retinal-containing proteins that depolarize/hyperpolarize the plasma membrane of nerve cells and, accordingly, excite/inhibit physiological activity of neurons, are described. The problem of what cells of the degenerative retina can be treated with what particular rhodopsins is discussed in detail. Viruses and promoters required for the rhodopsin gene delivery into the degenerative retina cells are described. In conclusion, main concepts and tasks associated with the optogenetic prosthetic treatment of degenerative retina employing rhodopsins are presented.
- Subjects
RETINA; OPTOGENETICS; NEURONS; RHODOPSIN; EYE; PROSTHETICS
- Publication
Biochemistry (00062979), 2019, Vol 84, Issue 5, p479
- ISSN
0006-2979
- Publication type
Article
- DOI
10.1134/S0006297919050031