We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Resveratrol-Loaded Chia Seed Oil-Based Nanogel as an Anti-Inflammatory in Adjuvant-Induced Arthritis.
- Authors
Afzal, Obaid; Altamimi, Abdulamalik S. A.; Alamri, Mubarak A.; Altharawi, Ali; Alossaimi, Manal A.; Akhtar, Md Sayeed; Tabassum, Fauzia; Almalki, Waleed H.; Singh, Tanuja
- Abstract
Natural anti-inflammatory nutraceuticals may be useful in preventing rheumatoid arthritis from worsening. Resveratrol (RV) and chia seed oil, having antioxidant potential, can assist in avoiding oxidative stress-related disorders. This investigation developed and evaluated resveratrol-loaded chia seed oil-based nanoemulsion (NE) gel formulations through in vitro and in vivo studies. The physical stability and in vitro drug permeability of the chosen formulations (NE1 to NE10) were studied. The optimized RV-loaded nanoemulsion (NE2) had droplets with an average size of 37.48 nm that were homogeneous in shape and had a zeta potential of −18 mV. RV-NE2, with a permeability of 98.21 ± 4.32 µg/cm2/h, was gelled with 1% carbopol-940P. A 28-day anti-arthritic assessment (body weight, paw edema, and levels of pro-inflammatory mediators including TNF-α, IL-6, IL-1β, and COX-2) following topical administration of RV-NE2 gel showed significant reversal of arthritic symptoms in arthritic Wistar rats induced by Freund's complete adjuvant injection. Therefore, RV-NE2 gel demonstrated the potential to achieve local therapeutic benefits in inflammatory arthritic conditions due to its increased topical bioavailability and balancing of pro-inflammatory mediators.
- Subjects
ANTI-inflammatory agents; RESVERATROL; NANOGELS; FUNCTIONAL foods; OXIDATIVE stress; ARTHRITIS
- Publication
Gels (2310-2861), 2023, Vol 9, Issue 2, p131
- ISSN
2310-2861
- Publication type
Article
- DOI
10.3390/gels9020131