We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Successful Hematopoietic Stem Cell Transplantation from a Matched Related Donor with BetaThalassemia Minor for Severe Aplastic Anemia.
- Authors
Mi Young Jung; Young Tae Lim; Hyunji Lim; Jeong Ok Hah; Jae Min Lee
- Abstract
The first-line treatment for severe aplastic anemia (SAA) patients is hematopoietic stem cell transplantation (HSCT), with full-matched related donors considered the most suitable. We report a case of SAA in which the patient successfully underwent HSCT from a donor with β-thalassemia minor. The patient in this case underwent HSCT from a human leukocyte antigen (HLA)-matched younger brother with β-thalassemia minor. A 7-year-old girl was referred to our facility following a 6-month history of easy bruising and pallor. Laboratory examinations showed pancytopenia and hypocellular bone marrow with cellularity of <5%. She was diagnosed with acquired SAA, and HLA typing of her family members was performed. Her younger brother was an HLA-matched sibling but had β-thalassemia minor. Since his hemoglobin levels were maintained at 10–11 d/dL, he was considered a suitable HSCT donor. The conditioning regimen included fludarabine, cyclophosphamide, and anti-thymocyte globulin. The CD34+ and CD3+ cell counts were 6.6 × 106 /kg and 0.48 × 108 /kg, respectively. White blood cell engraftment was evident on day +11. Regimen-associated toxicities, such as anorexia and enteritis, were mild; no infections occurred, and no symptoms of acute graft-versus-host disease (GVHD) were observed. The 30-day follow-up bone marrow examination revealed normocellular marrow with 80%–90% cellularity. Acute or chronic GVHD has not been reported, and good performance status has been observed throughout the 5 years after HSCT. β-thalassemia minor patients can be considered as bone marrow donors for SAA patients.
- Subjects
APLASTIC anemia; HEMATOPOIETIC stem cell transplantation; BETA-Thalassemia; HLA histocompatibility antigens; BONE marrow
- Publication
Children, 2020, Vol 7, Issue 10, p153
- ISSN
2227-9067
- Publication type
Article
- DOI
10.3390/children7100162