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- Title
Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice.
- Authors
Baohua Zhou; Comeau, Michael R.; de Smedt, Thibaut; Liggitt, H. Denny; Dahl, Martin E.; Lewis, David B.; Gyarmati, Dora; Theingi Aye; Campbell, Daniel J.; Ziegler, Steven F.
- Abstract
The cytokine thymic stromal lymphopoietin (TSLP) has been linked to human allergic inflammatory diseases. We show here that TSLP expression was increased in the lungs of mice with antigen-induced asthma, whereas TSLP receptor–deficient mice had considerably attenuated disease. Lung-specific expression of a Tslp transgene induced airway inflammation and hyperreactivity characterized by T helper type 2 cytokines and increased immunoglobulin E. The lungs of Tslp-transgenic mice showed massive infiltration of leukocytes, goblet cell hyperplasia and subepithelial fibrosis. TSLP was capable of activating bone marrow–derived dendritic cells to upregulate costimulatory molecules and produce the T helper type 2 cell–attracting chemokine CCL17. These findings suggest that TSLP is an important factor necessary and sufficient for the initiation of allergic airway inflammation.
- Subjects
CYTOKINES; CELLULAR immunity; ALLERGIES; IMMUNOREGULATION; LEUCOCYTES; BLOOD cells; INFLAMMATION; EXFOLIATIVE cytology; HYPERPLASIA
- Publication
Nature Immunology, 2005, Vol 6, Issue 10, p1047
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni1247