We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Epileptogenesis and Neurogenesis Share the Same Genes.
- Authors
Elliott, R.C.; Miles, M.F.; Lowenstein, D.H.; Bernardo, Larry S.
- Abstract
Overlapping Microarray Profiles of Dentate Gyrus Gene Expression during Development- and Epilepsy-associated Neurogenesis and Axon Outgrowth Neurogenesis and axon outgrowth are features shared by normal nervous system development and certain forms of epileptogenesis. This observation led to the hypothesis that some aspects of normal development and epileptogenesis have common molecular mechanisms. To test this hypothesis, we used DNA microarray analysis to characterize gene expression in the dentate gyrus and to identify genes exhibiting similar patterns of regulation during development and epileptogenesis. Of more than 8,000 sequences surveyed, more than 600 were regulated during development or epileptogenesis, and 37 of these were either upregulated or downregulated during both processes. In situ hybridization analysis of a subset of these “commonality genes” confirmed the patterns of regulation predicted by the microarray data in most cases and demonstrated various spatial and temporal patterns of commonality gene expression. Of the 25 named commonality genes in which some functional characteristics are known, 11 have been implicated in cell morphology and axon outgrowth or cellular proliferation and fate determination. This enrichment for candidate plasticity-related genes supports the concept that developmental mechanisms contribute to network alterations associated with epileptogenesis and offers a useful strategy for identifying molecules that may play a role in both of these processes.
- Subjects
EPILEPSY; DEVELOPMENTAL neurobiology; GENE expression; GENES; BRAIN diseases
- Publication
Epilepsy Currents, 2003, Vol 3, Issue 5, p162
- ISSN
1535-7597
- Publication type
Article
- DOI
10.1046/j.1535-7597.2003.03504.x