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- Title
Neopterin: A Potential Biomarker for Delirium in Elderly Patients.
- Authors
Egberts, Angelique; Wijnbeld, Eline H.A.; Fekkes, Durk; van der Ploeg, Milly A.; Ziere, Gijsbertus; Hooijkaas, Herbert; van der Cammen, Tischa J.M.; Mattace-Raso, Francesco U.S.
- Abstract
Background/Aims: The diagnosis of delirium is not supported by specific biomarkers. In a previous study, high neopterin levels were found in patients with a postoperative delirium. In the present study, we investigated levels of neopterin, interleukin-6 (IL-6) and insulin-like growth factor-1 (IGF-1) in acutely ill admitted elderly patients with and without a delirium. Methods: Plasma/serum levels ofneopterin, IL-6 and IGF-1 were determined in patients aged ≥65 years admitted to the wards of Internal Medicine and Geriatrics. Differences in biomarker levels between patients with and without a delirium were investigated by the analysis of variance in models adjusted for age, gender, comorbidities and eGFR (when appropriate). Results: Eighty-six patients were included; 23 of them with a delirium. In adjusted models, higher mean levels of neopterin (70.5 vs. 45.9 nmol/l, p = 0.009) and IL-6 (43.1 vs. 18.5 pg/ml, p = 0.034) and lower mean levels of IGF-1 (6.3 vs. 9.3 nmol/l, p = 0.007) were found in patients with a delirium compared to those without. Conclusions: The findings of this study suggest that neopterin might be a potential biomarker for delirium which, through oxidative stress and activation of the immune system, may play a role in the pathophysiology of delirium. © 2014 S. Karger AG, Basel
- Subjects
NETHERLANDS; DIAGNOSIS of delirium; HOSPITAL care of older people; ANALYSIS of variance; BIOMARKERS; BLOOD testing; COMPARATIVE studies; CONFIDENCE intervals; DELIRIUM; GLOMERULAR filtration rate; GROWTH factors; IMMUNE system; INTERLEUKINS; NEUROPSYCHOLOGICAL tests; NUCLEOTIDES; OARS Multidimensional Functional Assessment Questionnaire; QUESTIONNAIRES; REGRESSION analysis; RESEARCH funding; OXIDATIVE stress; CONTROL groups; STATISTICAL models; DESCRIPTIVE statistics; OLD age
- Publication
Dementia & Geriatric Cognitive Disorders, 2015, Vol 39, Issue 1/2, p116
- ISSN
1420-8008
- Publication type
Article
- DOI
10.1159/000366410