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- Title
Elemental Boron Nanoparticles: Production by Ultrasonication in Aqueous Medium and Application in Boron Neutron Capture Therapy.
- Authors
Uspenskii, S. A.; Khaptakhanova, P. A.; Zaboronok, A. A.; Kurkin, T. S.; Volkova, O. Yu.; Mechetina, L. V.; Taranin, A. V.; Kanygin, V. V.; Akira, Matsumura; Taskaev, S. Yu.
- Abstract
A method for producing elemental boron nanoparticles with a size of less than 100 nm by ultrasonic dispersion in a liquid medium and subsequent cascade fractionation is described. The resulting boron nanoparticles were used as a target for boron neutron capture therapy (BNCT). According to the results of an experimental preclinical study of BNCT with the synthesized boron nanoparticles, neutron irradiation for 1 h of T98G human glioma cells pre-incubated in a medium with boron nanoparticles (10, 20, and 40 ppm in terms of boron-10 isotope) leads to a significant suppression of cell viability.
- Subjects
BORON-neutron capture therapy; NEUTRON irradiation; SONICATION; BORON
- Publication
Doklady Chemistry, 2020, Vol 491, Issue 1, p45
- ISSN
0012-5008
- Publication type
Article
- DOI
10.1134/S0012500820030027