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- Title
Survival and division fate programs are preserved but retuned during the naïve to memory CD8<sup>+</sup> T‐cell transition.
- Authors
Heinzel, Susanne; Cheon, HoChan; Belz, Gabrielle T; Hodgkin, Philip D
- Abstract
Memory T cells are generated from naïve precursors undergoing proliferation during the initial immune response. Both naïve and memory T cells are maintained in a resting, quiescent state and respond to activation with a controlled proliferative burst and differentiation into effector cells. This similarity in the maintenance and response dynamics points to the preservation of key cellular fate programs; however, whether memory T cells have acquired intrinsic changes in these programs that may contribute to the enhanced immune protection in a recall response is not fully understood. Here we used a quantitative model–based analysis of proliferation and survival kinetics of in vitro–stimulated murine naïve and memory CD8+ T cells in response to homeostatic and activating signals to establish intrinsic similarities or differences within these cell types. We show that resting memory T cells display heightened sensitivity to homeostatic cytokines, responding to interleukin (IL)‐2 in addition to IL‐7 and IL‐15. The proliferative response to αCD3 was equal in size and kinetics, demonstrating that memory T cells undergo the same controlled division burst and automated return to quiescence as naïve T cells. However, perhaps surprisingly, we observed reduced expansion of αCD3‐stimulated memory T cells in response to activating signals αCD28 and IL‐2 compared with naïve T cells. Overall, we demonstrate that although sensitivities to cytokine and costimulatory signals have shifted, fate programs regulating the scale of the division burst are conserved in memory T cells.
- Subjects
IMMUNOLOGIC memory; T cells; SEED dormancy; CELL differentiation; IMMUNE response
- Publication
Immunology & Cell Biology, 2024, Vol 102, Issue 1, p46
- ISSN
0818-9641
- Publication type
Article
- DOI
10.1111/imcb.12699