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- Title
Genome-wide screen in obese pedigrees with type 2 diabetes mellitus from a defined Dutch population.
- Authors
van Tilburg, J.H.; Sandkuijl, L.A.; Franke, L.; Strengman, E.; Pearson, P.L.; van Haeften, T.W.; Wijmenga, C.
- Abstract
A genome scan was performed in obese type 2 diabetes mellitus pedigrees to identify susceptibility loci involved in obesity-driven type 2 diabetes mellitus. We studied the 20% most obese diabetes pedigrees from a confined Dutch population from around the town of Breda. Previously we, and others, have already shown that a susceptibility locus influencing obesity in diabetes may reside on chromosome 18p11. We now report evidence to also suggest linkage for type 2 diabetes in these obese pedigrees on chromosome regions 11p (genome-wide P-value ≤ 0·061) and 12q (genome-wide P-value ≤ 0·029), thereby confirming previous findings from corresponding regions. The linkage found in the Breda Cohort of type 2 diabetes patients is influenced by obesity. This supports the notion that a genetic predisposition to obesity is probably intertwined with a genetic predisposition to type 2 diabetes. Further efforts should address the question of how, on a genetic level, these two factors interact.
- Subjects
OVERWEIGHT persons; TYPE 2 diabetes
- Publication
European Journal of Clinical Investigation, 2003, Vol 33, Issue 12, p1070
- ISSN
0014-2972
- Publication type
Article
- DOI
10.1111/j.1365-2362.2003.01276.x