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- Title
SPECTROPHOTOMETRIC METHOD FOR DEVELOPMENT OF GUAIPHENESIN IN PHARMACEUTICAL DOSAGE FORM.
- Authors
Prabhu, Padmavathi P.; Das, Paramita; M., Navaneet Krishna; Subrahmanyam, E. V. S.
- Abstract
The estimation of Guaiphenesin was based on the reaction of alcoholic solution of 1, 10-phenanthroline (Ferroin indicator) in the presence of ferric chloride. The orange red colour complex formed with ferric chloride and 1, 10-phenanthroline, due to oxidation of Guaiphenesin by ferric chloride and thereby itself undergoing reduction from ferric ion to ferrous ion. Ferrous ion forms a complex with 1, 10-phenanthroline which showed max at 510nm. The method obeys Beer-Lambert's law in the concentration ranges of 10-60µg/ml of Guaiphenesin. The methods were validated for linearity, sensitivity, precision, accuracy, robustness and ruggedness.
- Subjects
GUAIFENESIN; SPECTROPHOTOMETRY; DOSAGE forms of drugs
- Publication
International Journal of Pharmaceutical, Chemical & Biological Sciences, 2013, Vol 3, Issue 3, p881
- ISSN
2249-9504
- Publication type
Article