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- Title
Severe Fever with Thrombocytopenia Syndrome.
- Authors
Seung Jin Yoo; Sang Taek Heo; Keun Hwa Lee
- Abstract
Severe fever with thrombocytopenia syndrome (SFTS) is a newly emerging infectious disease, caused by a novel species of Phlebovirus of Bunyaviridae family, in China, South Korea, and Japan. SFTS is primarily known as a tick borne disease, and human to human transmission is also possible in contact with infectious blood. Common clinical manifestations include fever, thrombocytopenia, and leukopenia as initial symptoms, and multiple organ dysfunction and failure manifest with disease progression. Whereas disease mortality is reported to be 12% to 30% in China, a recent report of cumulative SFTS cases indicated 47% in Korea. Risk factors associated with SFTS were age, presence of neurologic disturbance, serum enzyme levels, and elevated concentrations of certain cytokines. Diagnosis of SFTS is based on viral isolation, viral identification by polymerase chain reaction, and serologic identification of specific immunoglobulin G. Therapeutic guideline has not been formulated, but conservative management is the mainstream of treatment to prevent disease progression and fatal complications.
- Subjects
THROMBOCYTOPENIA; FEVER; COMMUNICABLE diseases; POLYMERASE chain reaction; IMMUNOGLOBULIN G; SEROLOGY
- Publication
Korean Journal of Critical Care Medicine, 2014, Vol 29, Issue 2, p59
- ISSN
1229-4802
- Publication type
Article
- DOI
10.4266/kjccm.2014.29.2.59