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- Title
Plasma pharmacokinetics, tissue concentrations and urine elimination after cephalothin intravenous administration to cats under surgical conditions.
- Authors
Albarellos, Gabriela A.; Montoya, Laura; Lupi, Martín P.; Passini, Sabrina M.; Lorenzini, Paula; Landoni, María Fabiana
- Abstract
Pharmacokinetic profile, tissue concentrations and urine elimination of cephalothin in cats under surgical conditions after a single intravenous dose (30 mg/kg) were studied. Initial plasma concentrations were high [Cp(0), 353.79±118.92 µg/mL], with fast and moderately wide distribution [T1/2(d) 0.14±0.10 h] [V(d(ss)) 0.19±0.03 L/kg] and rapid elimination (ClB, 0.16±0.03 L/h.kg; T1/2, 1.07±0.23 h; MRT, 1.16±0.21 h). Thirty to 60 minutes after intravenous administration, cephalothin tissue concentrations were in the range of 3.73 µg/g (testicle tissue) to 25.63 µg/g (uterus). Tissue/plasma concentrations rate was in a range of 0.04 (testicle) to 0.21 (uterus). Cephalothin urine elimination was 66.49% in the first 6 hours after administration. Cephalothin plasma concentrations remained above a minimum inhibitory concentration (MIC)=1 µg/mL up to 5.5 hours in all the studied cats. However, for MIC=8 µg/mL (MIC breakpoint) this time is reduced to 2.5 hours. This suggests that proper perioperative prophylactic use of cephalothin in cats requires a dose interval not longer than 2 hours.
- Subjects
PHARMACOKINETICS; URINALYSIS; TISSUE analysis; DRUG administration; INTRAVENOUS therapy; SURGICAL diseases; CEPHALOSPORINS; CATS as laboratory animals
- Publication
Veterinary Science Development, 2015, Vol 5, Issue 1, p37
- ISSN
2038-9698
- Publication type
Article
- DOI
10.4081/vsd.2015.5742