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- Title
Phage-Based Biosanitation Strategies for Minimizing Persistent Salmonella and Campylobacter Bacteria in Poultry.
- Authors
Jordá, Jaume; Lorenzo-Rebenaque, Laura; Montoro-Dasi, Laura; Marco-Fuertes, Ana; Vega, Santiago; Marin, Clara
- Abstract
Simple Summary: Implementing strategies to reduce harmful bacteria in food animal production plays a vital role in ensuring safer food for consumers. The food industry, especially in poultry and swine farming, faces significant challenges, including antibiotic-resistant and disinfection-resistant zoonotic bacteria. In this context, bacteriophages, which are viruses that attack bacteria, have emerged as a promising tool to control these bacteria throughout the food production process, from the animals and farms to the end product. Bacteriophages offer several advantages as a biocontrol agent, including their precision in targeting specific bacteria, ability to replicate, adaptability, low risk of toxicity and ease of isolation. Developing them as a biocontrol tool is particularly appealing because it aligns with the use of environmentally friendly "green" technology to combat harmful bacteria. This review provides a comprehensive overview of how phage-based strategies can help reduce persistent Salmonella and Campylobacter bacteria in poultry, contributing to safer food production. Control strategies to minimize pathogenic bacteria in food animal production are one of the key components in ensuring safer food for consumers. The most significant challenges confronting the food industry, particularly in the major poultry and swine sectors, are antibiotic resistance and resistance to cleaning and disinfection in zoonotic bacteria. In this context, bacteriophages have emerged as a promising tool for zoonotic bacteria control in the food industry, from animals and farm facilities to the final product. Phages are viruses that infect bacteria, with several advantages as a biocontrol agent such as high specificity, self-replication, self-limitation, continuous adaptation, low inherent toxicity and easy isolation. Their development as a biocontrol agent is of particular interest, as it would allow the application of a promising and even necessary "green" technology to combat pathogenic bacteria in the environment. However, bacteriophage applications have limitations, including selecting appropriate phages, legal restrictions, purification, dosage determination and bacterial resistance. Overcoming these limitations is crucial to enhance phage therapy's effectiveness against zoonotic bacteria in poultry. Thus, this review aims to provide a comprehensive view of the phage-biosanitation strategies for minimizing persistent Salmonella and Campylobacter bacteria in poultry.
- Subjects
BACTERIOPHAGES; CAMPYLOBACTER; SALMONELLA; PATHOGENIC bacteria; BACTERIA; POULTRY; SWINE farms
- Publication
Animals (2076-2615), 2023, Vol 13, Issue 24, p3826
- ISSN
2076-2615
- Publication type
Article
- DOI
10.3390/ani13243826