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- Title
Hormone replacement therapy and risks of various cancers in postmenopausal women with de novo or a history of endometriosis.
- Authors
Banghyun Lee; Minkyung Lee; Kyungjin Lee; Tae Kyoung Lee; Sung Ook Hwang
- Abstract
Objective: Combined estrogen and progesterone is currently recommended to improve menopausal symptoms in women with a history of endometriosis. However, the effect of hormone replacement therapy (HRT) on the malignant transformation of postmenopausal endometriosis remains unclear. We investigated the impact of HRT on various cancer occurrences in postmenopausal women with de novo or a history of endometriosis using Health Insurance Review and Assessment Service claims data. Methods: In datasets for 10 cancers (cervical, uterine, ovarian, breast, colon, gastric, liver, lung, pancreatic, and thyroid), women that received HRT (the HRT group) and those that did not (the control group) were selected by 1:1 matching those that met the study criteria. Results: In dataset for each cancer, incidence of each cancer was very low (0.2% to 1.5% in the HRT group and 0.2% to 1.3% in the control group) and were similar in the two groups. Mean duration of HRT was 1.3±2.1 years in dataset for each cancer. After adjusting for co-variables, the use of HRT was a significant risk factor for uterine cancer (p<0.05). However, the risk of liver cancer significantly decreased with duration of HRT (p<0.05). Moreover, the use of combined estrogen and progesterone significantly decreased the risks of liver and thyroid cancers (p<0.05), and the use of estrogen alone significantly decreased the risks of breast and lung cancers (p<0.05). Tibolone was not associated with the risk for each cancer. Conclusion: These results can be helpful to guide the use of HRT in women with de novo or a history of endometriosis.
- Subjects
HORMONE therapy; THYROID cancer; POSTMENOPAUSE; ENDOMETRIOSIS; DISEASE risk factors; CANCER patients; PELVIC pain
- Publication
Journal of Gynecologic Oncology, 2024, Vol 35, p14
- ISSN
2005-0380
- Publication type
Article
- DOI
10.3802/jgo.2024.35.S2.FP-U2