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- Title
Four Cases of T-Cell Malignancy in Childhood.
- Authors
MUCHI, HIROMU; OHIRA, MUTSURO; ISE, TOHRU; SHIMOYAMA, MASANORI; MINATO, KEISUKE; SAITO, HIROSHI; WATANABE, SHAW
- Abstract
Four cases of T-cell malignancy in childhood are reported. In the two older boys (seven [Case 1] and eight [Case 2] years old) the disease began as leukemia without a clinically detectable mediastinal mass. However, thymic involvement was found at autopsy in Case 1. Tumor cells of both patients had a rosetteforming capacity with sheep erythrocytes (ERFC), high terminal deoxynucleotidyl transferase (TdT) activity and a positive acid phosphatase (AcPase) reaction. These findings suggest that the tumor cells of Cases 1 and 2 originated from thymic T lymphocytes.The two younger patients (two [Case 3] and three [Case 4] years old) had cervical lymphadenopathy with mediastinal mass at onset, followed by leukemic change. The youngest patient (Case 3) lacked ERFC and the AcPase reaction, but had C3 Receptor (C3-R), human T-lymphocyte antigen (HLTA) and TdT activity. These findings indicate that the tumor cells of Case 3 are compatible with early thymic T lymphocytes. Tumor cells of Case 4 had ERFC, C3-R, HTLA, and slightly increased TdT activity. These findings suggest that the tumor cells of Case 4 originated from thymic T lymphocytes.Only one patient has maintained an initial complete remission for more than one year. The three others relapsed or had a leukemic conversion within 12 months of the initial remission and two died within 13 months. This indicates that childhood T-cell malignancies have a poor prognosis.
- Publication
Japanese Journal of Clinical Oncology, 1979, Vol 9, Issue 1, p175
- ISSN
0368-2811
- Publication type
Article