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- Title
Expression of p63 and CK5/6 in early-stage lung squamous cell carcinoma is not only an early diagnostic indicator but also correlates with a good prognosis.
- Authors
Ma, Yunfan; Fan, Mengying; Dai, Liang; Kang, Xiaozheng; Liu, Yiqiang; Sun, Yu; Xiong, Hongchao; Liang, Zhen; Yan, Wanpu; Chen, Keneng
- Abstract
Background Non-small cell lung cancer ( NSCLC) accounts for 80% of lung cancers, and lung squamous cell carcinoma ( SQCC) is one of the main types. Advances in the treatment of lung SQCC are lacking when compared to lung adenocarcinoma. The main treatment for early-stage SQCC is surgery. However, factors affecting the efficacy of surgical treatments for early-stage lung SQCC remain unclear. In this study, we examined the significance of commonly used lung SQCC diagnostic markers p63, p40, and cytokeratin ( CK)5/6 in prognosis. Methods Seventy-six cases of early-stage lung SQCC ( N0) were obtained from our lung cancer database ( January 2000 to December 2009). Tissue microarray and immunohistochemical ( IHC) staining were used to detect the expression of p63, p40, and CK5/6. The effect of the expression level of each marker on patients' survival was examined. Results Sensitivity and specificity of each marker for detecting lung SQCC was 87.0% and 81.0% for p63, 75.9% and 97.9% for p40, and 78.9% and 97.7% for CK5/6. Survival rates of patients with high expression levels of p63 or CK5/6 or both were higher than in patients with low expression levels ( P < 0.05). Expression levels of p40 had no effect on survival ( P > 0.05). Multivariate analysis showed that high levels of p63 expression p63+ CK5/6 co-expression were independent prognostic factors for good survival. Conclusion IHC staining detection of p63 and CK5/6 in specimens should be routinely performed in postoperative early-stage lung SQCC patients. Its significance lies not only in differential diagnosis, but also in determining prognosis.
- Subjects
CHINA; SQUAMOUS cell carcinoma; TUMOR markers; ACADEMIC medical centers; CHI-squared test; CONFIDENCE intervals; FISHER exact test; IMMUNOHISTOCHEMISTRY; LONGITUDINAL method; RESEARCH funding; LUNG tumors; STATISTICS; SURVIVAL; DATA analysis; PROPORTIONAL hazards models; RETROSPECTIVE studies; DATA analysis software; KAPLAN-Meier estimator; LOG-rank test; DIAGNOSIS; PROGNOSIS; THERAPEUTICS
- Publication
Thoracic Cancer, 2015, Vol 6, Issue 3, p288
- ISSN
1759-7706
- Publication type
Article
- DOI
10.1111/1759-7714.12181