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- Title
The Effect of Probiotic Supplements on Metabolic Parameters of People with Type 2 Diabetes in Greece—A Randomized, Double-Blind, Placebo-Controlled Study.
- Authors
Zikou, Eva; Dovrolis, Nikolas; Dimosthenopoulos, Charilaos; Gazouli, Maria; Makrilakis, Konstantinos
- Abstract
The role of probiotic supplementation in type 2 diabetes (T2D) treatment is controversial. The present study aimed to assess the effects of a multi-strain probiotic supplement (LactoLevureR (containing Lactobacillus acidophilus, Lactobacillus plantarum, Bifidobacterium lactis, and Saccharomyces boulardii)) over 6 months, primarily on glycemic control as well as on lipid levels and alterations in the gut microbiome, among individuals with T2D residing in Greece. A total of 91 adults with T2D (mean age [±SD] 65.12 ± 10.92 years, 62.6% males) were randomized to receive the probiotic supplement or a matching placebo capsule, once daily, for 6 months. Blood chemistries and anthropometric parameters were conducted every 3 months, and stool samples were collected at baseline and at 6 months. Significant reductions in HbA1c, fasting blood glucose, and total cholesterol were observed in participants treated with the probiotic supplement (n = 46) compared to the controls (n = 45), even after adjustment for a greater decrease in adiposity (waist circumference). Although there were no statistically significant differences in the diversity of the gut microbiome (α and β diversity), the administration of probiotics did influence several genera, metabolites, and key enzymes associated with diabetes. Overall, the administration of the multi-strain probiotic LactoLevureR over a 6-month period in individuals with T2D was well-tolerated and had a positive impact on metabolic parameters, alongside improvements in indices of adiposity.
- Subjects
GREECE; LIPID analysis; GLYCOSYLATED hemoglobin; FASTING; OBESITY; GLYCEMIC control; GUT microbiome; BLOOD chemical analysis; ANTHROPOMETRY; BLOOD sugar; TYPE 2 diabetes; PROBIOTICS; DIETARY supplements; TREATMENT effectiveness; RANDOMIZED controlled trials; COMPARATIVE studies; DESCRIPTIVE statistics; WAIST circumference; RESEARCH funding; EVALUATION
- Publication
Nutrients, 2023, Vol 15, Issue 21, p4663
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15214663