We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Brown Fat and Nutrition: Implications for Nutritional Interventions.
- Authors
Noriega, Lloyd; Yang, Cheng-Ying; Wang, Chih-Hao
- Abstract
Brown and beige adipocytes are renowned for their unique ability to generate heat through a mechanism known as thermogenesis. This process can be induced by exposure to cold, hormonal signals, drugs, and dietary factors. The activation of these thermogenic adipocytes holds promise for improving glucose metabolism, reducing fat accumulation, and enhancing insulin sensitivity. However, the translation of preclinical findings into effective clinical therapies poses challenges, warranting further research to identify the molecular mechanisms underlying the differentiation and function of brown and beige adipocytes. Consequently, research has focused on the development of drugs, such as mirabegron, ephedrine, and thyroid hormone, that mimic the effects of cold exposure to activate brown fat activity. Additionally, nutritional interventions have been explored as an alternative approach to minimize potential side effects. Brown fat and beige fat have emerged as promising targets for addressing nutritional imbalances, with the potential to develop strategies for mitigating the impact of metabolic diseases. Understanding the influence of nutritional factors on brown fat activity can facilitate the development of strategies to promote its activation and mitigate metabolic disorders.
- Subjects
NUTRITIONAL assessment; NUCLEOSIDES; NUTRITIONAL requirements; GLYCOSIDES; METABOLIC disorders; DIET therapy; FAT cells; OMEGA-3 fatty acids; BODY temperature regulation; MICRONUTRIENTS; DIETARY carbohydrates; OMEGA-6 fatty acids; ADIPOSE tissues
- Publication
Nutrients, 2023, Vol 15, Issue 18, p4072
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15184072