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- Title
The Effects of Dietary Interventions on Brain Aging and Neurological Diseases.
- Authors
Lobo, Fleur; Haase, Jonathan; Brandhorst, Sebastian
- Abstract
Dietary interventions can ameliorate age-related neurological decline. Decades of research of in vitro studies, animal models, and clinical trials support their ability and efficacy to improve behavioral outcomes by inducing biochemical and physiological changes that lead to a more resilient brain. Dietary interventions including calorie restriction, alternate day fasting, time restricted feeding, and fasting mimicking diets not only improve normal brain aging but also slow down, or even reverse, the progression of neurological diseases. In this review, we focus on the effects of intermittent and periodic fasting on improving phenotypic outcomes, such as cognitive and motor-coordination decline, in the normal aging brain through an increase in neurogenesis and synaptic plasticity, and decrease in neuroinflammation, mitochondrial dysfunction, and oxidative stress. We summarize the results of various dietary interventions in animal models of age-related neurological diseases such as Alzheimer's disease, Parkinson's disease, epilepsy, and Multiple Sclerosis and discuss the results of clinical trials that explore the feasibility of dietary interventions in the prevention and treatment of these diseases.
- Subjects
BRAIN physiology; NEUROLOGICAL disorder prevention; FASTING; DISEASE progression; BIOLOGICAL models; CELL differentiation; CLINICAL trials; ARTIFICIAL feeding; NEUROLOGICAL disorders; ANIMAL experimentation; MITOCHONDRIAL pathology; HEALTH outcome assessment; COGNITION; BEHAVIOR; NEUROPLASTICITY; NEUROINFLAMMATION; OXIDATIVE stress; AGING; MOTOR ability; PHENOTYPES
- Publication
Nutrients, 2022, Vol 14, Issue 23, p5086
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14235086